Ser334
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Home > Phosphorylation Site Page: > Ser334  -  LKB1 (human)

Site Information
DTKDRWRsMtVVPYL   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448146

In vivo Characterization
Methods used to characterize site in vivo:
[32P] ATP in vitro ( 1 ) , electrophoretic mobility shift ( 1 ) , immunoassay ( 2 ) , mutation of modification site ( 1 ) , phospho-antibody ( 2 )
Disease tissue studied:
breast cancer ( 1 ) , prostate cancer ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
Pim1 (human) ( 1 )
Kinases, in vitro:
Pim1 (human) ( 1 )
Treatments:
AZD1208 ( 1 ) , DHPCC-9 ( 1 )

Downstream Regulation
Effects of modification on biological processes:
carcinogenesis, induced ( 1 ) , cell growth, inhibited ( 1 )

Disease / Diagnostics Relevance
Relevant diseases:
HNSCC ( 2 )

References 

1

Mung KL, et al. (2021) PIM kinases inhibit AMPK activation and promote tumorigenicity by phosphorylating LKB1. Cell Commun Signal 19, 68
34193159   Curated Info

2

Frederick MJ, et al. (2011) Phosphoproteomic analysis of signaling pathways in head and neck squamous cell carcinoma patient samples. Am J Pathol 178, 548-71
21281788   Curated Info