Lys703
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Home > Sumoylation Site Page: > Lys703  -  STAT1 (human)

Site Information
PkGtGyIktELIsVs   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 3278913

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 1 , 4 ) , mutation of modification site ( 7 ) , western blotting ( 7 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Regulatory protein:
UBC9 (human) ( 7 )

Downstream Regulation
Effects of modification on STAT1:
phosphorylation ( 7 )

References 

1

Hendriks IA, et al. (2014) Uncovering global SUMOylation signaling networks in a site-specific manner. Nat Struct Mol Biol 21, 927-36
25218447   Curated Info

2

Impens F, Radoshevich L, Cossart P, Ribet D (2014) Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli. Proc Natl Acad Sci U S A 111, 12432-7
25114211   Curated Info

3

Grönholm J, et al. (2012) Structure-function analysis indicates that sumoylation modulates DNA-binding activity of STAT1. BMC Biochem 13, 20
23043228   Curated Info

4

Matic I, et al. (2010) Site-specific identification of SUMO-2 targets in cells reveals an inverted SUMOylation motif and a hydrophobic cluster SUMOylation motif. Mol Cell 39, 641-52
20797634   Curated Info

5

Zimnik S, Gaestel M, Niedenthal R (2009) Mutually exclusive STAT1 modifications identified by Ubc9/substrate dimerization-dependent SUMOylation. Nucleic Acids Res 37, e30
19174562   Curated Info

6

Niedenthal R (2009) Enhanced detection of in vivo SUMO conjugation by Ubc9 fusion-dependent sumoylation (UFDS). Methods Mol Biol 497, 63-79
19107411   Curated Info

7

Jakobs A, et al. (2007) Ubc9 fusion-directed SUMOylation (UFDS): a method to analyze function of protein SUMOylation. Nat Methods 4, 245-50
17277783   Curated Info

8

Ungureanu D, et al. (2005) SUMO-1 conjugation selectively modulates STAT1-mediated gene responses. Blood 106, 224-6
15761017   Curated Info

9

Ungureanu D, et al. (2003) PIAS proteins promote SUMO-1 conjugation to STAT1. Blood 102, 3311-3
12855578   Curated Info