Lys485
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Home > Acetylation Site Page: > Lys485  -  p70S6K iso2 (human)

Site Information
PNSGPYkkQAFPMIS   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 32640200

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , modification-specific antibody ( 2 ) , mutation of modification site ( 1 , 2 ) , western blotting ( 1 , 2 )
Relevant cell line - cell type - tissue:
COS7 (fibroblast) ( 2 ) , HEK293T (epithelial) ( 2 ) , mesangial-kidney ( 1 )

Upstream Regulation
Regulatory protein:
HDAC6 (human) ( 2 )
Treatments:
high_glucose ( 1 ) , nicotinamide ( 2 ) , siRNA ( 2 ) , trichostatin_A ( 2 )

Downstream Regulation
Effects of modification on p70S6K iso2:
enzymatic activity, inhibited ( 1 , 2 ) , molecular association, regulation ( 2 ) , phosphorylation ( 1 , 2 )
Effects of modification on biological processes:
transcription, inhibited ( 1 )
Inhibit interaction with:
Raptor (human) ( 2 )

References 

1

Das F, et al. (2019) Deacetylation of S6 kinase promotes high glucose-induced glomerular mesangial cell hypertrophy and matrix protein accumulation. J Biol Chem 294, 9440-9460
31028173   Curated Info

2

Hong S, et al. (2014) Cross-talk between sirtuin and mammalian target of rapamycin complex 1 (mTORC1) signaling in the regulation of S6 kinase 1 (S6K1) phosphorylation. J Biol Chem 289, 13132-41
24652283   Curated Info

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