Thr394
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Home > Phosphorylation Site Page: > Thr394  -  MOR-1 (rat)

Site Information
LENLEAEtAPLP___   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448128

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 , 2 , 3 ) , western blotting ( 2 )
Disease tissue studied:
neuroblastoma ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Treatments:
DAMGO ( 2 ) , etorphine ( 1 )

Downstream Regulation
Effects of modification on MOR-1:
receptor desensitization, altered ( 1 , 2 , 3 ) , receptor internalization, altered ( 1 )

References 

1

Qiu Y, Law PY, Loh HH (2003) Mu-opioid receptor desensitization: role of receptor phosphorylation, internalization, and representation. J Biol Chem 278, 36733-9
12860981   Curated Info

2

Deng HB, et al. (2000) Role for the C-terminus in agonist-induced mu opioid receptor phosphorylation and desensitization. Biochemistry 39, 5492-9
10820022   Curated Info

3

Pak Y, O'Dowd BF, George SR (1997) Agonist-induced desensitization of the mu opioid receptor is determined by threonine 394 preceded by acidic amino acids in the COOH-terminal tail. J Biol Chem 272, 24961-5
9312100   Curated Info