Thr180
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Home > Phosphorylation Site Page: > Thr180  -  MOR-1 (rat)

Site Information
VKALDFRtPRNAKIV   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448127

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 , 2 , 3 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
pituitary cancer ( 1 )
Relevant cell line - cell type - tissue:
'brain, striatum' ( 1 ) , 293 (epithelial) ( 1 ) , AtT20 (pituitary cell) ( 1 , 2 ) , oocyte ( 3 )

Upstream Regulation
Treatments:
DAMGO ( 1 )

Downstream Regulation
Effects of modification on MOR-1:
receptor desensitization, altered ( 2 , 3 )

References 

1

Petraschka M, et al. (2007) The absence of endogenous beta-endorphin selectively blocks phosphorylation and desensitization of mu opioid receptors following partial sciatic nerve ligation. Neuroscience 146, 1795-807
17467916   Curated Info

2

Celver J, et al. (2004) Distinct domains of the mu-opioid receptor control uncoupling and internalization. Mol Pharmacol 65, 528-37
14978231   Curated Info

3

Celver JP, et al. (2001) Threonine 180 is required for G-protein-coupled receptor kinase 3- and beta-arrestin 2-mediated desensitization of the mu-opioid receptor in Xenopus oocytes. J Biol Chem 276, 4894-900
11060299   Curated Info