Ser363
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Home > Phosphorylation Site Page: > Ser363  -  MOR-1 (rat)

Site Information
stIEQQNsTRVRQNt   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447783

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 3 ) , mass spectrometry ( 1 ) , mutation of modification site ( 2 , 3 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 1 , 2 , 3 ) , MEF (fibroblast) ( 2 )

Upstream Regulation
Kinases, in vitro:
PKCA (human) ( 1 )
Treatments:
DAMGO ( 3 )

Downstream Regulation
Effects of modification on MOR-1:
molecular association, regulation ( 1 ) , receptor desensitization, altered ( 2 ) , receptor internalization, altered ( 3 )
Induce interaction with:
ARR3 (human) ( 1 ) , ARRB2 (human) ( 1 )

References 

1

Chen YJ, et al. (2013) Identification of phosphorylation sites in the COOH-terminal tail of the μ-opioid receptor. J Neurochem 124, 189-99
23106126   Curated Info

2

Chu J, Zheng H, Loh HH, Law PY (2008) Morphine-induced mu-opioid receptor rapid desensitization is independent of receptor phosphorylation and beta-arrestins. Cell Signal 20, 1616-24
18558479   Curated Info

3

El Kouhen R, et al. (2001) Phosphorylation of Ser363, Thr370, and Ser375 residues within the carboxyl tail differentially regulates mu-opioid receptor internalization. J Biol Chem 276, 12774-80
11278523   Curated Info