Tyr724
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Home > Phosphorylation Site Page: > Tyr724  -  FGFR3 (human)

Site Information
ANCTHDLyMIMRECW   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448116

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 1 , 2 , 3 ) , mutation of modification site ( 4 , 5 )
Disease tissue studied:
multiple myeloma ( 2 , 3 )
Relevant cell line - cell type - tissue:
3T3 (fibroblast) [SHP-2 (mouse), homozygous knockout] ( 4 ) , 3T3 (fibroblast) ( 5 ) , CHO (fibroblast) ( 5 ) , HEK293T (epithelial) ( 4 , 5 ) , KMS-11 (B lymphocyte) ( 1 , 2 ) , KMS-18 (B lymphocyte) ( 3 )

Upstream Regulation
Putative in vivo kinases:
FGFR3 (human) ( 5 )
Treatments:
FGF1 ( 5 ) , heparin sodium ( 5 )

Downstream Regulation
Effects of modification on FGFR3:
enzymatic activity, induced ( 4 , 5 ) , molecular association, regulation ( 4 ) , phosphorylation ( 5 )
Effects of modification on biological processes:
cell growth, altered ( 5 ) , transcription, altered ( 5 )
Induce interaction with:
SH2-B-beta (mouse) ( 4 )

References 

1

St-Germain JR, et al. (2009) Multiple myeloma phosphotyrosine proteomic profile associated with FGFR3 expression, ligand activation, and drug inhibition. Proc Natl Acad Sci U S A 106, 20127-32
19901323   Curated Info

2

Gu T (2006) CST Curation Set: 1727; Year: 2006; Biosample/Treatment: cell line, KMS-11/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

3

Gu T (2005) CST Curation Set: 874; Year: 2005; Biosample/Treatment: cell line, KMS-18/-; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

4

Kong M, Wang CS, Donoghue DJ (2002) Interaction of fibroblast growth factor receptor 3 and the adapter protein SH2-B. A role in STAT5 activation. J Biol Chem 277, 15962-70
11827956   Curated Info

5

Hart KC, Robertson SC, Donoghue DJ (2001) Identification of tyrosine residues in constitutively activated fibroblast growth factor receptor 3 involved in mitogenesis, Stat activation, and phosphatidylinositol 3-kinase activation. Mol Biol Cell 12, 931-42
11294897   Curated Info

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