Ser518
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Home > Phosphorylation Site Page: > Ser518  -  PRP4 (mouse)

Site Information
GMKVEQEsssDDNLE   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 3195692

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 1 , 2 , 3 , 4 )
Disease tissue studied:
leukemia ( 1 ) , acute myelogenous leukemia ( 1 ) , melanoma skin cancer ( 4 )
Relevant cell line - cell type - tissue:
32Dcl3 (myeloid) [FLT3 (mouse), transfection, chimera with human FLT3-ITD mutant (corresponding to wild type P36888 ( 3 ) , 32Dcl3 (myeloid) ( 3 ) , blood ( 1 ) , macrophage-bone marrow ( 2 ) , macrophage-bone marrow [DUSP1 (mouse), homozygous knockout] ( 2 ) , skin [mGluR1 (mouse), transgenic, TG mutant mice] ( 4 )

Upstream Regulation
Regulatory protein:
FLT3 (mouse) ( 3 )

References 

1

Trost M, et al. (2012) Posttranslational regulation of self-renewal capacity: insights from proteome and phosphoproteome analyses of stem cell leukemia. Blood 120, e17-27
22802335   Curated Info

2

Weintz G, et al. (2010) The phosphoproteome of toll-like receptor-activated macrophages. Mol Syst Biol 6, 371
20531401   Curated Info

3

Choudhary C, et al. (2009) Mislocalized activation of oncogenic RTKs switches downstream signaling outcomes. Mol Cell 36, 326-39
19854140   Curated Info

4

Zanivan S, et al. (2008) Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry. J Proteome Res 7, 5314-26
19367708   Curated Info