Ser649
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Home > Phosphorylation Site Page: > Ser649  -  TNIK (mouse)

Site Information
KVPQRTTsIsPALAR   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 3215502

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 2 , 3 , 4 , 5 )
Relevant cell line - cell type - tissue:
'fat, brown' ( 5 ) , brain ( 3 , 5 ) , heart ( 2 , 5 ) , kidney ( 5 ) , liver ( 5 ) , lung ( 5 ) , MEF (fibroblast) [TSC2 (mouse), homozygous knockout] ( 4 ) , pancreas ( 5 ) , spleen ( 5 ) , testis ( 5 )

Upstream Regulation
Regulatory protein:
ADRB1 (mouse) ( 2 )

References 

1

Sacco F, et al. (2016) Glucose-regulated and drug-perturbed phosphoproteome reveals molecular mechanisms controlling insulin secretion. Nat Commun 7, 13250
27841257   Curated Info

2

Lundby A, et al. (2013) In vivo phosphoproteomics analysis reveals the cardiac targets of β-adrenergic receptor signaling. Sci Signal 6, rs11
23737553   Curated Info

3

Trinidad JC, et al. (2012) Global identification and characterization of both O-GlcNAcylation and phosphorylation at the murine synapse. Mol Cell Proteomics 11, 215-29
22645316   Curated Info

4

Yu Y, et al. (2011) Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling. Science 332, 1322-6
21659605   Curated Info

5

Huttlin EL, et al. (2010) A tissue-specific atlas of mouse protein phosphorylation and expression. Cell 143, 1174-89
21183079   Curated Info