Ser138

Site Information
KPRGPRRsksDsDtL SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 3189391

In vivo Characterization
Methods used to characterize site in vivo:	mass spectrometry ( 1 , 2 , 3 , 4 , 5 )
Relevant cell line - cell type - tissue:	'fat, brown' ( 3 ) , 32Dcl3 (myeloid) [FLT3 (mouse), transfection, chimera with human FLT3-ITD mutant (corresponding to wild type P36888 ( 5 ) , 32Dcl3 (myeloid) ( 5 ) , brain ( 3 ) , lung ( 3 ) , macrophage-bone marrow ( 4 ) , macrophage-bone marrow [DUSP1 (mouse), homozygous knockout] ( 4 ) , macrophage-peritoneum ( 1 ) , macrophage-peritoneum [MPRIP (mouse), homozygous knockout] ( 1 ) , MEF (fibroblast) [TSC2 (mouse), homozygous knockout] ( 2 ) , MEF (fibroblast) ( 2 ) , spleen ( 3 )

In vivo Characterization

Methods used to characterize site in vivo:

mass spectrometry ( 1 , 2 , 3 , 4 , 5 )

Relevant cell line - cell type - tissue:

'fat, brown' ( 3 ) , 32Dcl3 (myeloid) [FLT3 (mouse), transfection, chimera with human FLT3-ITD mutant (corresponding to wild type P36888 ( 5 ) , 32Dcl3 (myeloid) ( 5 ) , brain ( 3 ) , lung ( 3 ) , macrophage-bone marrow ( 4 ) , macrophage-bone marrow [DUSP1 (mouse), homozygous knockout] ( 4 ) , macrophage-peritoneum ( 1 ) , macrophage-peritoneum [MPRIP (mouse), homozygous knockout] ( 1 ) , MEF (fibroblast) [TSC2 (mouse), homozygous knockout] ( 2 ) , MEF (fibroblast) ( 2 ) , spleen ( 3 )

Upstream Regulation
Treatments:	LPS ( 4 )

References
1	Wu X, et al. (2012) Investigation of receptor interacting protein (RIP3)-dependent protein phosphorylation by quantitative phosphoproteomics. Mol Cell Proteomics 11, 1640-51 22942356 Curated Info
2	Yu Y, et al. (2011) Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling. Science 332, 1322-6 21659605 Curated Info
3	Huttlin EL, et al. (2010) A tissue-specific atlas of mouse protein phosphorylation and expression. Cell 143, 1174-89 21183079 Curated Info
4	Weintz G, et al. (2010) The phosphoproteome of toll-like receptor-activated macrophages. Mol Syst Biol 6, 371 20531401 Curated Info
5	Choudhary C, et al. (2009) Mislocalized activation of oncogenic RTKs switches downstream signaling outcomes. Mol Cell 36, 326-39 19854140 Curated Info