Ser1330
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Home > Phosphorylation Site Page: > Ser1330  -  SRC-3 (human)

Site Information
PAFGRVSsPPNAMMS   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 3217872

In vivo Characterization
Methods used to characterize site in vivo:
immunoassay ( 2 ) , immunoprecipitation ( 2 ) , mass spectrometry ( 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 10 , 11 ) , mutation of modification site ( 1 , 2 ) , phospho-antibody ( 2 ) , western blotting ( 2 )
Disease tissue studied:
breast cancer ( 5 ) , breast ductal carcinoma ( 5 ) , HER2 positive breast cancer ( 4 ) , luminal A breast cancer ( 4 ) , luminal B breast cancer ( 4 ) , breast cancer, surrounding tissue ( 4 ) , breast cancer, triple negative ( 4 , 5 ) , liver cancer ( 2 ) , hepatocellular carcinoma ( 2 ) , lung cancer ( 7 ) , non-small cell lung adenocarcinoma ( 7 ) , pancreatic ductal adenocarcinoma ( 6 )
Relevant cell line - cell type - tissue:
'pancreatic, ductal'-pancreas ( 6 ) , 293 (epithelial) ( 2 ) , breast ( 4 , 5 ) , HCC (hepatic) ( 2 ) , HEK293T (epithelial) ( 1 ) , HeLa (cervical) ( 3 , 10 , 11 ) , HepG2 (hepatic) ( 2 ) , HMEC (endothelial) ( 1 ) , Jurkat (T lymphocyte) ( 8 ) , K562 (erythroid) ( 10 ) , lung ( 7 ) , MHCC97H (hepatic) ( 2 ) , SMMC7721 (hepatocyte) ( 2 )

Upstream Regulation
Regulatory protein:
GTF2H4 (human) ( 1 )
Putative in vivo kinases:
DYRK3 (human) ( 2 )
Kinases, in vitro:
DYRK3 (human) ( 2 )
Treatments:
staurosporine ( 2 )

Downstream Regulation
Effects of modification on SRC-3:
molecular association, regulation ( 1 , 2 )
Effects of modification on biological processes:
carcinogenesis, inhibited ( 2 ) , cell growth, inhibited ( 2 ) , signaling pathway regulation ( 1 , 2 ) , transcription, inhibited ( 2 )
Induce interaction with:
NFkB-p65 (human) ( 1 )
Inhibit interaction with:
ATF-4 (human) ( 2 ) , DNA ( 2 )

Disease / Diagnostics Relevance
Relevant diseases:
hepatocellular carcinoma ( 2 )

References 

1

Fang Z, et al. (2024) GTF2H4 regulates partial EndMT via NF-κB activation through NCOA3 phosphorylation in ischemic diseases. Innovation (Camb) 5, 100565
38379791   Curated Info

2

Ma F, et al. (2019) Dual-Specificity Tyrosine Phosphorylation-Regulated Kinase 3 Loss Activates Purine Metabolism and Promotes Hepatocellular Carcinoma Progression. Hepatology
31066068   Curated Info

3

Huang H, et al. (2016) Simultaneous Enrichment of Cysteine-containing Peptides and Phosphopeptides Using a Cysteine-specific Phosphonate Adaptable Tag (CysPAT) in Combination with titanium dioxide (TiO2) Chromatography. Mol Cell Proteomics 15, 3282-3296
27281782   Curated Info

4

Mertins P, et al. (2016) Proteogenomics connects somatic mutations to signalling in breast cancer. Nature 534, 55-62
27251275   Curated Info

5

Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704
24719451   Curated Info

6

Britton D, et al. (2014) Quantification of pancreatic cancer proteome and phosphorylome: indicates molecular events likely contributing to cancer and activity of drug targets. PLoS One 9, e90948
24670416   Curated Info

7

Schweppe DK, Rigas JR, Gerber SA (2013) Quantitative phosphoproteomic profiling of human non-small cell lung cancer tumors. J Proteomics 91, 286-96
23911959   Curated Info

8

Mertins P, et al. (2013) Integrated proteomic analysis of post-translational modifications by serial enrichment. Nat Methods 10, 634-7
23749302   Curated Info

9

Shiromizu T, et al. (2013) Identification of missing proteins in the neXtProt database and unregistered phosphopeptides in the PhosphoSitePlus database as part of the Chromosome-centric Human Proteome Project. J Proteome Res 12, 2414-21
23312004   Curated Info

10

Zhou H, et al. (2013) Toward a comprehensive characterization of a human cancer cell phosphoproteome. J Proteome Res 12, 260-71
23186163   Curated Info

11

Dephoure N, et al. (2008) A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A 105, 10762-7
18669648   Curated Info