Ser748
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Home > Phosphorylation Site Page: > Ser748  -  SEC63 (human)

Site Information
DsEGFEDsFEEEEEE   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 3215004

In vivo Characterization
Methods used to characterize site in vivo:
[32P] ATP in vitro ( 2 ) , mass spectrometry ( 1 , 3 )
Disease tissue studied:
HER2 positive breast cancer ( 1 ) , luminal A breast cancer ( 1 ) , luminal B breast cancer ( 1 ) , breast cancer, triple negative ( 1 ) , liver cancer ( 2 )
Relevant cell line - cell type - tissue:
breast ( 1 ) , HeLa (cervical) ( 3 ) , HepG2 (hepatic) ( 2 )

Upstream Regulation
Putative in vivo kinases:
CK2A1 (human) ( 2 ) , CK2B (human) ( 2 )
Kinases, in vitro:
CK2A1 (human) ( 2 ) , CK2B (human) ( 2 )

Downstream Regulation
Effects of modification on SEC63:
molecular association, regulation ( 2 )
Induce interaction with:
SEC62 (human) ( 2 )

References 

1

Mertins P, et al. (2016) Proteogenomics connects somatic mutations to signalling in breast cancer. Nature 534, 55-62
27251275   Curated Info

2

Ampofo E, et al. (2013) CK2 phosphorylation of human Sec63 regulates its interaction with Sec62. Biochim Biophys Acta 1830, 2938-45
23287549   Curated Info

3

Dephoure N, et al. (2008) A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A 105, 10762-7
18669648   Curated Info