Ser275

Site Information
sKRTHQRsKsDAtAS SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 3214803

In vivo Characterization
Methods used to characterize site in vivo:	mass spectrometry ( 2 , 3 , 4 , 5 )
Disease tissue studied:	breast cancer ( 3 ) , lung cancer ( 3 ) , non-small cell lung cancer ( 3 )
Relevant cell line - cell type - tissue:	293E (epithelial) ( 4 ) , BT-20 (breast cell) ( 3 ) , H2009 (pulmonary) ( 3 ) , H2077 (pulmonary) ( 3 ) , H2887 (pulmonary) ( 3 ) , H322M (pulmonary) ( 3 ) , HCC1359 (pulmonary) ( 3 ) , HCC1937 (breast cell) ( 3 ) , HCC2279 (pulmonary) ( 3 ) , HCC366 (pulmonary) ( 3 ) , HCC4006 (pulmonary) ( 3 ) , HCC78 (pulmonary) ( 3 ) , HCC827 (pulmonary) ( 3 ) , HeLa (cervical) ( 5 ) , HOP62 (pulmonary) ( 3 ) , K562 (erythroid) ( 2 ) , LCLC-103H (pulmonary) ( 3 ) , MCF-7 (breast cell) ( 3 ) , MDA-MB-468 (breast cell) ( 3 ) , NCI-H1395 (pulmonary) ( 3 ) , NCI-H1568 (pulmonary) ( 3 ) , NCI-H157 (pulmonary) ( 3 ) , NCI-H1666 (pulmonary) ( 3 ) , NCI-H2030 (pulmonary) ( 3 ) , NCI-H2172 (pulmonary) ( 3 ) , NCI-H322 (pulmonary) ( 3 ) , NCI-H520 (squamous) ( 3 ) , NCI-H647 (pulmonary) ( 3 ) , PC9 (pulmonary) ( 3 )

Upstream Regulation
Treatments:	rapamycin ( 4 )

References
1	Shiromizu T, et al. (2013) Identification of missing proteins in the neXtProt database and unregistered phosphopeptides in the PhosphoSitePlus database as part of the Chromosome-centric Human Proteome Project. J Proteome Res 12, 2414-21 23312004 Curated Info
2	Zhou H, et al. (2013) Toward a comprehensive characterization of a human cancer cell phosphoproteome. J Proteome Res 12, 260-71 23186163 Curated Info
3	Klammer M, et al. (2012) Phosphosignature predicts dasatinib response in non-small cell lung cancer. Mol Cell Proteomics 11, 651-68 22617229 Curated Info
4	Hsu PP, et al. (2011) The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling. Science 332, 1317-22 21659604 Curated Info
5	Dephoure N, et al. (2008) A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A 105, 10762-7 18669648 Curated Info