Thr194
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Home > Phosphorylation Site Page: > Thr194  -  MASTL (human)

Site Information
NMMDILTtPSMAkPR   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 3209097

In vivo Characterization
Methods used to characterize site in vivo:
immunoassay ( 1 ) , immunoprecipitation ( 1 ) , mass spectrometry ( 2 , 3 , 4 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
cervical cancer ( 2 ) , cervical adenocarcinoma ( 2 )
Relevant cell line - cell type - tissue:
HEK293T (epithelial) ( 1 ) , HeLa (cervical) ( 1 , 3 , 4 ) , HeLa S3 (cervical) ( 2 )

Upstream Regulation
Regulatory protein:
CTDP1 (human) ( 1 )
Putative in vivo kinases:
CDK1 (human) ( 1 )
Kinases, in vitro:
CDK2 (human) ( 1 )
Putative upstream phosphatases:
PPP2R2A (human) ( 1 ) , PPP2R2D (human) ( 1 )
Treatments:
1NM-PP1 ( 1 ) , calyculin_A ( 1 ) , okadaic_acid ( 1 ) , RO-3306 ( 1 ) , siRNA ( 1 ) , tautomycin ( 1 )

Downstream Regulation
Effects of modification on MASTL:
activity, induced ( 1 ) , intracellular localization ( 1 )
Effects of modification on biological processes:
cell cycle regulation ( 1 )

References 

1

Hégarat N, et al. (2014) PP2A/B55 and Fcp1 regulate Greatwall and Ensa dephosphorylation during mitotic exit. PLoS Genet 10, e1004004
24391510   Curated Info

2

Olsen JV, et al. (2010) Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci Signal 3, ra3
20068231   Curated Info

3

Chen RQ, et al. (2009) CDC25B mediates rapamycin-induced oncogenic responses in cancer cells. Cancer Res 69, 2663-8
19276368   Curated Info

4

Dephoure N, et al. (2008) A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A 105, 10762-7
18669648   Curated Info

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