Ser875
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Home > Phosphorylation Site Page: > Ser875  -  MASTL (human)

Site Information
tAQHLtVsGFsL___   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 3209091

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 6 ) , mass spectrometry ( 2 , 4 , 6 , 7 , 8 , 9 ) , mass spectrometry (in vitro) ( 6 ) , mutation of modification site ( 6 ) , phospho-antibody ( 6 ) , western blotting ( 6 )
Disease tissue studied:
cervical cancer ( 7 ) , cervical adenocarcinoma ( 7 )
Relevant cell line - cell type - tissue:
E.coli (bacterial) ( 1 ) , HeLa (cervical) ( 2 , 9 ) , HeLa S3 (cervical) ( 7 , 8 ) , K562 (erythroid) ( 4 ) , oocyte ( 6 )

Upstream Regulation
Kinases, in vitro:
CDK1 (human) ( 6 ) , PLK1 (frog) ( 6 )

Downstream Regulation
Effects of modification on MASTL:
enzymatic activity, induced ( 1 , 6 ) , phosphorylation ( 6 ) , protein conformation ( 6 )
Effects of modification on biological processes:
cell cycle regulation ( 6 )
Induce interaction with:
RSK2 (human) ( 6 )

References 

1

Ocasio CA, et al. (2016) A first generation inhibitor of human Greatwall kinase, enabled by structural and functional characterisation of a minimal kinase domain construct. Oncotarget 7, 71182-71197
27563826   Curated Info

2

Sharma K, et al. (2014) Ultradeep human phosphoproteome reveals a distinct regulatory nature of Tyr and Ser/Thr-based signaling. Cell Rep 8, 1583-94
25159151   Curated Info

3

Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704
24719451   Curated Info

4

Zhou H, et al. (2013) Toward a comprehensive characterization of a human cancer cell phosphoproteome. J Proteome Res 12, 260-71
23186163   Curated Info

5

Klammer M, et al. (2012) Phosphosignature predicts dasatinib response in non-small cell lung cancer. Mol Cell Proteomics 11, 651-68
22617229   Curated Info

6

Vigneron S, et al. (2011) Characterization of the mechanisms controlling Greatwall activity. Mol Cell Biol 31, 2262-75
21444715   Curated Info

7

Olsen JV, et al. (2010) Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci Signal 3, ra3
20068231   Curated Info

8

Daub H, et al. (2008) Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. Mol Cell 31, 438-48
18691976   Curated Info

9

Dephoure N, et al. (2008) A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A 105, 10762-7
18669648   Curated Info

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