Ser146

Site Information
NQFsPIssPEPEDPI SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 3208230

In vivo Characterization
Methods used to characterize site in vivo:	mass spectrometry ( 1 , 2 , 3 , 4 , 6 , 7 , 8 , 9 )
Disease tissue studied:	breast cancer ( 2 ) , HER2 positive breast cancer ( 1 ) , luminal A breast cancer ( 1 ) , luminal B breast cancer ( 1 ) , breast cancer, triple negative ( 1 ) , cervical cancer ( 7 ) , cervical adenocarcinoma ( 7 ) , leukemia ( 6 ) , acute myelogenous leukemia ( 6 ) , lung cancer ( 3 ) , non-small cell lung cancer ( 3 )
Relevant cell line - cell type - tissue:	breast ( 1 ) , Calu 6 (pulmonary) ( 3 ) , Flp-In T-Rex-293 (epithelial) [PRKD1 (human), genetic knockin] ( 4 ) , Flp-In T-Rex-293 (epithelial) ( 4 ) , H2009 (pulmonary) ( 3 ) , H2077 (pulmonary) ( 3 ) , H2887 (pulmonary) ( 3 ) , H322M (pulmonary) ( 3 ) , HeLa (cervical) ( 8 , 9 ) , HeLa S3 (cervical) ( 7 ) , K562 (erythroid) ( 8 ) , KG-1 (myeloid) ( 6 ) , NCI-H1648 (pulmonary) ( 3 ) , SKBr3 (breast cell) ( 2 )

Upstream Regulation
Treatments:	dasatinib ( 8 ) , nocodazole ( 7 )

References
1	Mertins P, et al. (2016) Proteogenomics connects somatic mutations to signalling in breast cancer. Nature 534, 55-62 27251275 Curated Info
2	Imami K, et al. (2012) Temporal profiling of lapatinib-suppressed phosphorylation signals in EGFR/HER2 pathways. Mol Cell Proteomics 11, 1741-57 22964224 Curated Info
3	Klammer M, et al. (2012) Phosphosignature predicts dasatinib response in non-small cell lung cancer. Mol Cell Proteomics 11, 651-68 22617229 Curated Info
4	Franz-Wachtel M, et al. (2012) Global detection of protein kinase D-dependent phosphorylation events in nocodazole-treated human cells. Mol Cell Proteomics 11, 160-70 22496350 Curated Info
5	Beli P, et al. (2012) Proteomic Investigations Reveal a Role for RNA Processing Factor THRAP3 in the DNA Damage Response. Mol Cell 46, 212-25 22424773 Curated Info
6	Weber C, Schreiber TB, Daub H (2012) Dual phosphoproteomics and chemical proteomics analysis of erlotinib and gefitinib interference in acute myeloid leukemia cells. J Proteomics 75, 1343-56 22115753 Curated Info
7	Olsen JV, et al. (2010) Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci Signal 3, ra3 20068231 Curated Info
8	Pan C, Olsen JV, Daub H, Mann M (2009) Global effects of kinase inhibitors on signaling networks revealed by quantitative phosphoproteomics. Mol Cell Proteomics 8, 2796-808 19651622 Curated Info
9	Dephoure N, et al. (2008) A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A 105, 10762-7 18669648 Curated Info