Thr245

Site Information
RAsLsDLtDLEDIEG SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 3208095

In vivo Characterization
Methods used to characterize site in vivo:	mass spectrometry ( 1 , 2 , 3 , 5 , 6 , 7 )
Disease tissue studied:	hepatocellular carcinoma, surrounding tissue ( 6 ) , lung cancer ( 1 , 3 ) , non-small cell lung cancer ( 3 ) , non-small cell lung adenocarcinoma ( 1 )
Relevant cell line - cell type - tissue:	H2077 (pulmonary) ( 3 ) , H322M (pulmonary) ( 3 ) , HCC2279 (pulmonary) ( 3 ) , HCC366 (pulmonary) ( 3 ) , HCC78 (pulmonary) ( 3 ) , HeLa (cervical) ( 5 ) , hepatocyte-liver ( 6 ) , liver ( 2 ) , LOU-NH91 (squamous) ( 3 ) , NCI-H2172 (pulmonary) ( 3 ) , NCI-H460 (pulmonary) ( 3 ) , NCI-H520 (squamous) ( 3 ) , PC9 (pulmonary) ( 1 , 3 ) , PC9-IR (pulmonary) ( 1 ) , TERT20 ('stem, mesenchymal') ( 7 )

References
1	Tsai CF, et al. (2015) Large-scale determination of absolute phosphorylation stoichiometries in human cells by motif-targeting quantitative proteomics. Nat Commun 6, 6622 25814448 Curated Info
2	Bian Y, et al. (2014) An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J Proteomics 96, 253-62 24275569 Curated Info
3	Klammer M, et al. (2012) Phosphosignature predicts dasatinib response in non-small cell lung cancer. Mol Cell Proteomics 11, 651-68 22617229 Curated Info
4	Beli P, et al. (2012) Proteomic Investigations Reveal a Role for RNA Processing Factor THRAP3 in the DNA Damage Response. Mol Cell 46, 212-25 22424773 Curated Info
5	Kettenbach AN, et al. (2011) Quantitative phosphoproteomics identifies substrates and functional modules of aurora and polo-like kinase activities in mitotic cells. Sci Signal 4, rs5 21712546 Curated Info
6	Han G, et al. (2010) Phosphoproteome analysis of human liver tissue by long-gradient nanoflow LC coupled with multiple stage MS analysis. Electrophoresis 31, 1080-9 20166139 Curated Info
7	Thingholm TE, et al. (2008) TiO2-Based Phosphoproteomic Analysis of the Plasma Membrane and the Effects of Phosphatase Inhibitor Treatment. J Proteome Res 7, 3304-3313 18578522 Curated Info