Ser634
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Home > Phosphorylation Site Page: > Ser634  -  SHCBP1 (human)

Site Information
QIKKKRLsELGITQA   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 3206817

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 4 ) , mass spectrometry ( 1 , 2 , 4 , 5 , 6 , 7 , 8 , 9 ) , microscopy-colocalization with upstream kinase ( 4 ) , mutation of modification site ( 4 ) , phospho-antibody ( 4 ) , western blotting ( 4 )
Disease tissue studied:
breast cancer ( 5 ) , luminal A breast cancer ( 1 ) , luminal B breast cancer ( 1 ) , breast cancer, triple negative ( 1 ) , cervical cancer ( 7 ) , cervical adenocarcinoma ( 7 )
Relevant cell line - cell type - tissue:
breast ( 1 ) , BT-20 (breast cell) ( 5 ) , BT-549 (breast cell) ( 5 ) , HeLa (cervical) ( 2 , 4 , 6 , 9 ) , HeLa S3 (cervical) ( 7 ) , Jurkat (T lymphocyte) ( 8 ) , MDA-MB-231 (breast cell) ( 5 ) , MDA-MB-468 (breast cell) ( 5 )

Upstream Regulation
Putative in vivo kinases:
AurB (human) ( 4 )
Kinases, in vitro:
AurB (human) ( 4 )
Treatments:
BI2536 ( 4 ) , CIAP ( 4 ) , nocodazole ( 7 ) , VX-680 ( 4 )

Downstream Regulation
Effects of modification on SHCBP1:
intracellular localization ( 4 ) , molecular association, regulation ( 4 )
Effects of modification on biological processes:
cell cycle regulation ( 4 )
Inhibit interaction with:
MgcRacGAP (human) ( 4 )

References 

1

Mertins P, et al. (2016) Proteogenomics connects somatic mutations to signalling in breast cancer. Nature 534, 55-62
27251275   Curated Info

2

Sharma K, et al. (2014) Ultradeep human phosphoproteome reveals a distinct regulatory nature of Tyr and Ser/Thr-based signaling. Cell Rep 8, 1583-94
25159151   Curated Info

3

Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704
24719451   Curated Info

4

Asano E, et al. (2013) The Aurora-B-mediated phosphorylation of SHCBP1 regulates cytokinetic furrow ingression. J Cell Sci 126, 3263-70
23704356   Curated Info

5

Klammer M, et al. (2012) Phosphosignature predicts dasatinib response in non-small cell lung cancer. Mol Cell Proteomics 11, 651-68
22617229   Curated Info

6

Hegemann B, et al. (2011) Systematic phosphorylation analysis of human mitotic protein complexes. Sci Signal 4, rs12
22067460   Curated Info

7

Olsen JV, et al. (2010) Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci Signal 3, ra3
20068231   Curated Info

8

Mayya V, et al. (2009) Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. Sci Signal 2, ra46
19690332   Curated Info

9

Dephoure N, et al. (2008) A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A 105, 10762-7
18669648   Curated Info

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