Ser273
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Home > Phosphorylation Site Page: > Ser273  -  SHCBP1 (human)

Site Information
SSLSNCNsDsEQENI   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 3206802

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 3 ) , mass spectrometry ( 1 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 ) , mutation of modification site ( 2 , 3 ) , phospho-antibody ( 3 ) , western blotting ( 3 )
Disease tissue studied:
bladder cancer ( 2 ) , breast cancer ( 5 ) , gastric carcinoma ( 3 ) , neuroblastoma ( 1 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 9 ) , CLB-Bar ( 1 ) , HeLa (cervical) ( 4 , 7 , 8 , 10 ) , HeLa_BI (cervical) ( 8 ) , HeLa_Hesp (cervical) ( 8 ) , HeLa_LOG (cervical) ( 8 ) , HeLa_NOC (cervical) ( 8 ) , HMLER ('stem, breast cancer') [CXCR4 (human), knockdown] ( 5 ) , HMLER ('stem, breast cancer') ( 5 ) , Jurkat (T lymphocyte) ( 6 ) , SNU-216 (gastric) ( 3 ) , T24 (bladder cell) ( 2 )

Upstream Regulation
Treatments:
EGF ( 2 , 3 )

Downstream Regulation
Effects of modification on SHCBP1:
intracellular localization ( 2 , 3 )
Effects of modification on biological processes:
carcinogenesis, induced ( 2 , 3 ) , cell cycle regulation ( 3 ) , cell growth, induced ( 3 ) , cell motility, induced ( 2 )

References 

1

Borenäs M, et al. (2024) ALK signaling primes the DNA damage response sensitizing ALK-driven neuroblastoma to therapeutic ATR inhibition. Proc Natl Acad Sci U S A 121, e2315242121
38154064   Curated Info

2

Yin H, et al. (2022) EGF-induced nuclear translocation of SHCBP1 promotes bladder cancer progression through inhibiting RACGAP1-mediated RAC1 inactivation. Cell Death Dis 13, 39
35013128   Curated Info

3

Shi W, et al. (2021) Hyperactivation of HER2-SHCBP1-PLK1 axis promotes tumor cell mitosis and impairs trastuzumab sensitivity to gastric cancer. Nat Commun 12, 2812
33990570   Curated Info

4

Sharma K, et al. (2014) Ultradeep human phosphoproteome reveals a distinct regulatory nature of Tyr and Ser/Thr-based signaling. Cell Rep 8, 1583-94
25159151   Curated Info

5

Yi T, et al. (2014) Quantitative phosphoproteomic analysis reveals system-wide signaling pathways downstream of SDF-1/CXCR4 in breast cancer stem cells. Proc Natl Acad Sci U S A 111, E2182-90
24782546   Curated Info

6

Guo A (2011) CST Curation Set: 11848; Year: 2011; Biosample/Treatment: cell line, Jurkat/calyculin_A & pervanadate; Disease: T cell leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[ST]P
Curated Info

7

Kettenbach AN, et al. (2011) Quantitative phosphoproteomics identifies substrates and functional modules of aurora and polo-like kinase activities in mitotic cells. Sci Signal 4, rs5
21712546   Curated Info

8

Hegemann B, et al. (2011) Systematic phosphorylation analysis of human mitotic protein complexes. Sci Signal 4, rs12
22067460   Curated Info

9

Gauci S, et al. (2009) Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. Anal Chem 81, 4493-501
19413330   Curated Info

10

Dephoure N, et al. (2008) A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A 105, 10762-7
18669648   Curated Info

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