Ser855
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Home > Phosphorylation Site Page: > Ser855  -  Raptor (human)

Site Information
QRVLDtssLtQsAPA   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 3205935

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 1 ) , mass spectrometry ( 2 , 3 , 4 ) , phospho-antibody ( 1 , 3 ) , western blotting ( 1 , 3 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Regulatory protein:
RHEB (human) ( 3 )
Putative in vivo kinases:
ULK1 (human) ( 1 ) , ULK2 (human) ( 1 )
Kinases, in vitro:
ULK1 (human) ( 1 )
Treatments:
insulin ( 2 ) , KU-0063794 ( 1 ) , PD98059 ( 2 ) , rapamycin ( 2 ) , siRNA ( 1 ) , wortmannin ( 2 )

Downstream Regulation
Effects of modification on Raptor:
molecular association, regulation ( 1 )
Effects of modification on biological processes:
signaling pathway regulation ( 1 )
Inhibit interaction with:
4E-BP1 (human) ( 1 )

References 

1

Dunlop EA, et al. (2011) ULK1 inhibits mTORC1 signaling, promotes multisite Raptor phosphorylation and hinders substrate binding. Autophagy 7, 737-47
21460630   Curated Info

2

Langlais P, Yi Z, Mandarino LJ (2011) The Identification of Raptor as a Substrate for p44/42 MAPK. Endocrinology 152, 1264-73
21325048   Curated Info

3

Foster KG, et al. (2010) Regulation of mTOR complex 1 (mTORC1) by raptor Ser863 and multisite phosphorylation. J Biol Chem 285, 80-94
19864431   Curated Info

4

Gwinn DM, Asara JM, Shaw RJ (2010) Raptor is phosphorylated by cdc2 during mitosis. PLoS One 5, e9197
20169205   Curated Info