Ser38

Site Information
FKVNASAsSLKKKQI SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 3197465

In vivo Characterization
Methods used to characterize site in vivo:	mass spectrometry ( 2 , 3 , 4 , 6 ) , mutation of modification site ( 1 ) , western blotting ( 1 )
Disease tissue studied:	breast cancer ( 3 ) , HER2 positive breast cancer ( 2 ) , luminal A breast cancer ( 2 ) , luminal B breast cancer ( 2 ) , breast cancer, surrounding tissue ( 2 ) , breast cancer, triple negative ( 2 , 3 ) , esophageal cancer ( 1 ) , esophageal carcinoma ( 1 ) , cancer, squamous cell carcinoma ( 1 )
Relevant cell line - cell type - tissue:	breast ( 2 , 3 ) , HeLa (cervical) ( 6 ) , Kyse150 (esophageal) ( 1 ) , Kyse180 (esophageal) ( 1 ) , liver ( 4 )

Downstream Regulation
Effects of modification on biological processes:	cell growth, inhibited ( 1 ) , cell motility, inhibited ( 1 ) , cytoskeletal reorganization ( 1 )

References
1	Zeng FM, et al. (2017) Fascin phosphorylation sites combine to regulate esophageal squamous cancer cell behavior. Amino Acids 49, 943-955 28251354 Curated Info
2	Mertins P, et al. (2016) Proteogenomics connects somatic mutations to signalling in breast cancer. Nature 534, 55-62 27251275 Curated Info
3	Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704 24719451 Curated Info
4	Bian Y, et al. (2014) An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J Proteomics 96, 253-62 24275569 Curated Info
5	Shiromizu T, et al. (2013) Identification of missing proteins in the neXtProt database and unregistered phosphopeptides in the PhosphoSitePlus database as part of the Chromosome-centric Human Proteome Project. J Proteome Res 12, 2414-21 23312004 Curated Info
6	Dephoure N, et al. (2008) A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A 105, 10762-7 18669648 Curated Info