Ser435
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Home > Phosphorylation Site Page: > Ser435  -  TRF1 (human)

Site Information
KKLKLIssDsED___   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 3192037

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 5 ) , mass spectrometry ( 1 , 2 , 4 , 6 ) , mutation of modification site ( 5 ) , western blotting ( 5 )
Disease tissue studied:
ataxia-telangiectasia ( 5 ) , leukemia ( 4 ) , acute myelogenous leukemia ( 4 ) , lung cancer ( 1 ) , non-small cell lung cancer ( 1 ) , fibrosarcoma of soft tissue ( 5 )
Relevant cell line - cell type - tissue:
AT22IJE-T (fibroblast) ( 5 ) , Flp-In T-Rex-293 (epithelial) [PRKD1 (human), genetic knockin] ( 2 ) , H2009 (pulmonary) ( 1 ) , H2077 (pulmonary) ( 1 ) , H2887 (pulmonary) ( 1 ) , H322M (pulmonary) ( 1 ) , HCC366 (pulmonary) ( 1 ) , HCC78 (pulmonary) ( 1 ) , HEK293T (epithelial) ( 5 ) , HeLa (cervical) ( 5 , 6 ) , HOP62 (pulmonary) ( 1 ) , HT1080 (fibroblast) ( 5 ) , KG-1 (myeloid) ( 4 ) , LOU-NH91 (squamous) ( 1 ) , NCI-H1395 (pulmonary) ( 1 ) , NCI-H1568 (pulmonary) ( 1 ) , NCI-H2030 (pulmonary) ( 1 ) , NCI-H322 (pulmonary) ( 1 ) , NCI-H460 (pulmonary) ( 1 ) , NCI-H520 (squamous) ( 1 ) , NCI-H647 (pulmonary) ( 1 ) , PC9 (pulmonary) ( 1 )

Upstream Regulation
Putative in vivo kinases:
PLK1 (human) ( 5 )
Kinases, in vitro:
PLK1 (human) ( 5 )

Downstream Regulation
Effects of modification on biological processes:
apoptosis, induced ( 5 )
Induce interaction with:
DNA ( 5 )

References 

1

Klammer M, et al. (2012) Phosphosignature predicts dasatinib response in non-small cell lung cancer. Mol Cell Proteomics 11, 651-68
22617229   Curated Info

2

Franz-Wachtel M, et al. (2012) Global detection of protein kinase D-dependent phosphorylation events in nocodazole-treated human cells. Mol Cell Proteomics 11, 160-70
22496350   Curated Info

3

Beli P, et al. (2012) Proteomic Investigations Reveal a Role for RNA Processing Factor THRAP3 in the DNA Damage Response. Mol Cell 46, 212-25
22424773   Curated Info

4

Weber C, Schreiber TB, Daub H (2012) Dual phosphoproteomics and chemical proteomics analysis of erlotinib and gefitinib interference in acute myeloid leukemia cells. J Proteomics 75, 1343-56
22115753   Curated Info

5

Wu ZQ, Yang X, Weber G, Liu X (2008) Plk1 phosphorylation of TRF1 is essential for its binding to telomeres. J Biol Chem 283, 25503-13
18625707   Curated Info

6

Dephoure N, et al. (2008) A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A 105, 10762-7
18669648   Curated Info

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