Tyr67

Site Information
SKKKRIIyDsDsEsE SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 3189904

In vivo Characterization
Methods used to characterize site in vivo:	mass spectrometry ( 1 , 3 , 4 , 5 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 )
Disease tissue studied:	breast cancer ( 1 ) , cervical cancer ( 10 ) , cervical adenocarcinoma ( 10 ) , leukemia ( 4 ) , acute myelogenous leukemia ( 4 ) , hepatocellular carcinoma, surrounding tissue ( 9 ) , lung cancer ( 3 ) , non-small cell lung cancer ( 3 )
Relevant cell line - cell type - tissue:	293 (epithelial) [AT1 (human), transfection, AT1R stable transfected HEK293] ( 8 ) , 293 (epithelial) ( 12 ) , Calu 6 (pulmonary) ( 3 ) , Flp-In T-Rex-293 (epithelial) [PRKD1 (human), genetic knockin] ( 5 ) , Flp-In T-Rex-293 (epithelial) ( 5 ) , H2009 (pulmonary) ( 3 ) , H2077 (pulmonary) ( 3 ) , H2887 (pulmonary) ( 3 ) , H322M (pulmonary) ( 3 ) , HCC1359 (pulmonary) ( 3 ) , HCC2279 (pulmonary) ( 3 ) , HCC366 (pulmonary) ( 3 ) , HCC4006 (pulmonary) ( 3 ) , HCC78 (pulmonary) ( 3 ) , HCC827 (pulmonary) ( 3 ) , HCT116 (intestinal) ( 13 ) , HeLa (cervical) ( 11 , 13 , 15 ) , HeLa S3 (cervical) ( 10 ) , hepatocyte-liver ( 9 ) , HMLER ('stem, breast cancer') [CXCR4 (human), knockdown] ( 1 ) , HMLER ('stem, breast cancer') ( 1 ) , HOP62 (pulmonary) ( 3 ) , HUES-9 ('stem, embryonic') ( 7 ) , Jurkat (T lymphocyte) ( 14 ) , LCLC-103H (pulmonary) ( 3 ) , LOU-NH91 (squamous) ( 3 ) , MV4-11 (macrophage) ( 4 ) , NCI-H1395 (pulmonary) ( 3 ) , NCI-H1568 (pulmonary) ( 3 ) , NCI-H157 (pulmonary) ( 3 ) , NCI-H1648 (pulmonary) ( 3 ) , NCI-H1666 (pulmonary) ( 3 ) , NCI-H2030 (pulmonary) ( 3 ) , NCI-H2172 (pulmonary) ( 3 ) , NCI-H322 (pulmonary) ( 3 ) , NCI-H460 (pulmonary) ( 3 ) , NCI-H520 (squamous) ( 3 ) , NCI-H647 (pulmonary) ( 3 ) , P31/FUJ (erythroid) ( 4 ) , PC9 (pulmonary) ( 3 )

Upstream Regulation
Treatments:	U0126 ( 11 )

References
1	Yi T, et al. (2014) Quantitative phosphoproteomic analysis reveals system-wide signaling pathways downstream of SDF-1/CXCR4 in breast cancer stem cells. Proc Natl Acad Sci U S A 111, E2182-90 24782546 Curated Info
2	Schweppe DK, Rigas JR, Gerber SA (2013) Quantitative phosphoproteomic profiling of human non-small cell lung cancer tumors. J Proteomics 91, 286-96 23911959 Curated Info
3	Klammer M, et al. (2012) Phosphosignature predicts dasatinib response in non-small cell lung cancer. Mol Cell Proteomics 11, 651-68 22617229 Curated Info
4	Alcolea MP, et al. (2012) Phosphoproteomic analysis of leukemia cells under basal and drug-treated conditions identifies markers of kinase pathway activation and mechanisms of resistance. Mol Cell Proteomics 11, 453-66 22547687 Curated Info
5	Franz-Wachtel M, et al. (2012) Global detection of protein kinase D-dependent phosphorylation events in nocodazole-treated human cells. Mol Cell Proteomics 11, 160-70 22496350 Curated Info
6	Beli P, et al. (2012) Proteomic Investigations Reveal a Role for RNA Processing Factor THRAP3 in the DNA Damage Response. Mol Cell 46, 212-25 22424773 Curated Info
7	Rigbolt KT, et al. (2011) System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. Sci Signal 4, rs3 21406692 Curated Info
8	Christensen GL, et al. (2010) Quantitative phosphoproteomics dissection of seven-transmembrane receptor signaling using full and biased agonists. Mol Cell Proteomics 9, 1540-53 20363803 Curated Info
9	Han G, et al. (2010) Phosphoproteome analysis of human liver tissue by long-gradient nanoflow LC coupled with multiple stage MS analysis. Electrophoresis 31, 1080-9 20166139 Curated Info
10	Olsen JV, et al. (2010) Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci Signal 3, ra3 20068231 Curated Info
11	Pan C, Olsen JV, Daub H, Mann M (2009) Global effects of kinase inhibitors on signaling networks revealed by quantitative phosphoproteomics. Mol Cell Proteomics 8, 2796-808 19651622 Curated Info
12	Gauci S, et al. (2009) Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. Anal Chem 81, 4493-501 19413330 Curated Info
13	Nagano K, et al. (2009) Phosphoproteomic analysis of distinct tumor cell lines in response to nocodazole treatment. Proteomics 9, 2861-74 19415658 Curated Info
14	Mayya V, et al. (2009) Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. Sci Signal 2, ra46 19690332 Curated Info
15	Dephoure N, et al. (2008) A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A 105, 10762-7 18669648 Curated Info