Lys914
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Home > Sumoylation Site Page: > Lys914  -  JAK2 (human)

Site Information
HDNIVkYkGVCYSAG   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 31899107

In vivo Characterization
Methods used to characterize site in vivo:
electrophoretic mobility shift ( 1 ) , immunoprecipitation ( 1 ) , modification-specific antibody ( 1 ) , mutation of modification site ( 1 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 1 )

Upstream Regulation
Treatments:
GH ( 1 ) , heating ( 1 ) , siRNA ( 1 ) , starvation ( 1 ) , staurosporine ( 1 )

Downstream Regulation
Effects of modification on JAK2:
intracellular localization ( 1 ) , molecular association, regulation ( 1 )
Inhibit interaction with:
GH receptor (human) ( 1 )

References 

1

Sedek M, Strous GJ (2013) SUMOylation is a regulator of the translocation of Jak2 between nucleus and cytosol. Biochem J 453, 231-9
23581279   Curated Info

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