Ser79
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Home > Phosphorylation Site Page: > Ser79  -  RARG (human)

Site Information
EMVPSsPsPPPPPRV   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 455544

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 3 ) , mass spectrometry ( 2 ) , mutation of modification site ( 1 , 3 ) , phospho-antibody ( 1 ) , phosphopeptide mapping ( 3 ) , western blotting ( 1 , 3 )
Relevant cell line - cell type - tissue:
COS (fibroblast) ( 3 ) , MCF-7 (breast cell) ( 2 ) , MEF (fibroblast) ( 1 )

Upstream Regulation
Kinases, in vitro:
CDK7 (human) ( 3 ) , ERK1 (human) ( 3 ) , GTF2F1 (human) ( 3 )
Treatments:
retinoic_acid ( 1 )

Downstream Regulation
Effects of modification on RARG:
activity, induced ( 3 )
Effects of modification on biological processes:
transcription, induced ( 3 )

References 

1

Chebaro Y, et al. (2017) Allosteric Regulation in the Ligand Binding Domain of Retinoic Acid Receptorγ. PLoS One 12, e0171043
28125680   Curated Info

2

Sacco F, et al. (2016) Deep Proteomics of Breast Cancer Cells Reveals that Metformin Rewires Signaling Networks Away from a Pro-growth State. Cell Syst 2, 159-71
27135362   Curated Info

3

Bastien J, et al. (2000) TFIIH interacts with the retinoic acid receptor gamma and phosphorylates its AF-1-activating domain through cdk7. J Biol Chem 275, 21896-904
10748061   Curated Info

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