Ser145
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Home > Phosphorylation Site Page: > Ser145  -  TAGLN2 (human)

Site Information
ArDDGLFsGDPNWFP   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 31885453

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mass spectrometry ( 2 , 3 , 4 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
luminal A breast cancer ( 2 ) , breast cancer, triple negative ( 2 ) , lung cancer ( 3 ) , non-small cell lung adenocarcinoma ( 3 ) , pancreatic cancer ( 1 ) , pancreatic carcinoma ( 1 )
Relevant cell line - cell type - tissue:
'pancreatic, ductal' ( 1 ) , breast ( 2 ) , BxPC-3 (pancreatic) ( 1 ) , HeLa (cervical) ( 4 ) , PC9 (pulmonary) ( 3 ) , SW1990 (pancreatic) ( 1 )

Upstream Regulation
Regulatory protein:
KRas (human) ( 1 )
Putative in vivo kinases:
ERK2 (human) ( 1 )
Kinases, in vitro:
ERK2 (human) ( 1 )
Treatments:
LY294002 ( 1 ) , U0126 ( 1 )

Downstream Regulation
Effects of modification on TAGLN2:
protein stabilization ( 1 )
Effects of modification on biological processes:
carcinogenesis, induced ( 1 ) , cell growth, induced ( 1 )

Disease / Diagnostics Relevance
Relevant diseases:
pancreatic ductal adenocarcinoma ( 1 )

References 

1

Sun Y, et al. (2018) Transgelin-2 is a novel target of KRAS-ERK signaling involved in the development of pancreatic cancer. J Exp Clin Cancer Res 37, 166
30041673   Curated Info

2

Mertins P, et al. (2016) Proteogenomics connects somatic mutations to signalling in breast cancer. Nature 534, 55-62
27251275   Curated Info

3

Tsai CF, et al. (2015) Large-scale determination of absolute phosphorylation stoichiometries in human cells by motif-targeting quantitative proteomics. Nat Commun 6, 6622
25814448   Curated Info

4

Kettenbach AN, et al. (2011) Quantitative phosphoproteomics identifies substrates and functional modules of aurora and polo-like kinase activities in mitotic cells. Sci Signal 4, rs5
21712546   Curated Info