Ser40
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Home > Phosphorylation Site Page: > Ser40  -  XIAP (human)

Site Information
FANFPSGsPVSAstL   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 31884865

In vivo Characterization
Methods used to characterize site in vivo:
flow cytometry ( 1 ) , immunoprecipitation ( 1 ) , mass spectrometry ( 2 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
bone cancer ( 1 )
Relevant cell line - cell type - tissue:
HeLa (cervical) ( 1 ) , Jurkat (T lymphocyte) ( 2 ) , U2OS (bone cell) ( 1 )

Upstream Regulation
Kinases, in vitro:
CDK1 (human) ( 1 )
Treatments:
purvalanol ( 1 ) , RO-3306 ( 1 ) , wortmannin ( 1 )

Downstream Regulation
Effects of modification on XIAP:
molecular association, regulation ( 1 )
Effects of modification on biological processes:
apoptosis, induced ( 1 )
Inhibit interaction with:
CASP3 (human) ( 1 ) , CASP7 (human) ( 1 )

References 

1

Hou Y, Allan LA, Clarke PR (2017) Phosphorylation of XIAP by CDK1-cyclin-B1 controls mitotic cell death. J Cell Sci 130, 502-511
27927753   Curated Info

2

Mertins P, et al. (2013) Integrated proteomic analysis of post-translational modifications by serial enrichment. Nat Methods 10, 634-7
23749302   Curated Info