Ser40
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Home > Phosphorylation Site Page: > Ser40  -  DRP1 (human)

Site Information
TQSSGKSsVLEsLVG   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 31872528

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 2 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
Alzheimer's disease ( 1 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 1 ) , HeLa (cervical) ( 2 ) , neuron-'brain, hippocampus' ( 1 )

Upstream Regulation
Putative in vivo kinases:
GSK3B (human) ( 1 )
Kinases, in vitro:
GSK3B (human) ( 1 )

Downstream Regulation
Effects of modification on DRP1:
enzymatic activity, induced ( 1 ) , intracellular localization ( 1 )
Effects of modification on biological processes:
apoptosis, induced ( 1 )

Disease / Diagnostics Relevance
Relevant diseases:
Alzheimer's disease ( 1 )

References 

1

Yan J, et al. (2015) Blockage of GSK3β-mediated Drp1 phosphorylation provides neuroprotection in neuronal and mouse models of Alzheimer's disease. Neurobiol Aging 36, 211-27
25192600   Curated Info

2

Kettenbach AN, et al. (2011) Quantitative phosphoproteomics identifies substrates and functional modules of aurora and polo-like kinase activities in mitotic cells. Sci Signal 4, rs5
21712546   Curated Info

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