Ser886
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Home > Phosphorylation Site Page: > Ser886  -  FANCD2 (human)

Site Information
TSSsDtLsEEkNsEC   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 31867427

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mass spectrometry ( 1 , 2 , 3 ) , mutation of modification site ( 1 )
Disease tissue studied:
cervical cancer ( 1 ) , cervical adenocarcinoma ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
CK2A1 (human) ( 1 )
Kinases, in vitro:
CK2A1 (human) ( 1 )
Treatments:
silmitasertib ( 1 )

Downstream Regulation
Effects of modification on FANCD2:
activity, inhibited ( 1 ) , intracellular localization ( 1 ) , molecular association, regulation ( 1 ) , ubiquitination ( 1 )
Effects of modification on biological processes:
cell cycle regulation ( 1 ) , DNA repair, inhibited ( 1 ) , signaling pathway regulation ( 1 )
Inhibit interaction with:
DNA ( 1 )

References 

1

Lopez-Martinez D, et al. (2019) Phosphorylation of FANCD2 Inhibits the FANCD2/FANCI Complex and Suppresses the Fanconi Anemia Pathway in the Absence of DNA Damage. Cell Rep 27, 2990-3005.e5
31167143   Curated Info

2

Sharma K, et al. (2014) Ultradeep human phosphoproteome reveals a distinct regulatory nature of Tyr and Ser/Thr-based signaling. Cell Rep 8, 1583-94
25159151   Curated Info

3

Kettenbach AN, et al. (2011) Quantitative phosphoproteomics identifies substrates and functional modules of aurora and polo-like kinase activities in mitotic cells. Sci Signal 4, rs5
21712546   Curated Info