Ser259
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Home > Phosphorylation Site Page: > Ser259  -  NFAT3 (human)

Site Information
APGPtPAsPRPAsPC   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 31859079

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mass spectrometry ( 2 ) , mutation of modification site ( 1 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 1 ) , HaCaT (keratinocyte) ( 1 ) , HeLa (cervical) ( 2 )

Upstream Regulation
Kinases, in vitro:
CDK3 (human) ( 1 )

Downstream Regulation
Effects of modification on biological processes:
cell growth, induced ( 1 ) , transcription, induced ( 1 )

Disease / Diagnostics Relevance
Relevant diseases:
BCC ( 1 ) , melanoma skin cancer ( 1 ) , cancer, squamous cell carcinoma ( 1 )

References 

1

Xiao T, et al. (2017) Phosphorylation of NFAT3 by CDK3 induces cell transformation and promotes tumor growth in skin cancer. Oncogene 36, 2835-2845
27893713   Curated Info

2

Kettenbach AN, et al. (2011) Quantitative phosphoproteomics identifies substrates and functional modules of aurora and polo-like kinase activities in mitotic cells. Sci Signal 4, rs5
21712546   Curated Info