Ser49
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Home > Phosphorylation Site Page: > Ser49  -  RAD54L (human)

Site Information
QIQECFLsPFRkPLS   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 31855101

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 1 , 2 , 3 ) , mutation of modification site ( 1 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:
E.coli (bacterial) ( 1 ) , HeLa (cervical) ( 2 , 3 ) , Sf21 ( 1 )

Upstream Regulation
Kinases, in vitro:
CDK2 (human) ( 1 )
Treatments:
MLN8054 ( 3 )

Downstream Regulation
Effects of modification on RAD54L:
protein conformation ( 1 )
Effects of modification on biological processes:
DNA repair, inhibited ( 1 )
Inhibit interaction with:
DNA ( 1 )

References 

1

Goyal N, et al. (2018) RAD54 N-terminal domain is a DNA sensor that couples ATP hydrolysis with branch migration of Holliday junctions. Nat Commun 9, 34
29295984   Curated Info

2

Sharma K, et al. (2014) Ultradeep human phosphoproteome reveals a distinct regulatory nature of Tyr and Ser/Thr-based signaling. Cell Rep 8, 1583-94
25159151   Curated Info

3

Kettenbach AN, et al. (2011) Quantitative phosphoproteomics identifies substrates and functional modules of aurora and polo-like kinase activities in mitotic cells. Sci Signal 4, rs5
21712546   Curated Info