Thr1041
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Home > Phosphorylation Site Page: > Thr1041  -  LATS2 (human)

Site Information
EHAFyEFtFRRFFDD   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 31843001

In vivo Characterization
Methods used to characterize site in vivo:
immunoassay ( 6 ) , immunoprecipitation ( 4 ) , mutation of modification site ( 4 , 6 ) , phospho-antibody ( 1 , 2 , 3 , 5 , 6 ) , western blotting ( 1 , 2 , 3 , 4 , 5 , 6 )
Disease tissue studied:
brain cancer ( 2 ) , glioblastoma ( 2 ) , glioma ( 2 ) , breast cancer ( 6 ) , colorectal cancer ( 3 , 6 ) , colorectal carcinoma ( 3 , 6 ) , lung cancer ( 6 ) , non-small cell lung cancer ( 6 ) , non-small cell lung adenocarcinoma ( 6 ) , OSCC ( 5 ) , prostate cancer ( 3 ) , cancer, squamous cell carcinoma ( 3 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Regulatory protein:
FRK (human) ( 2 ) , MST1 (human) ( 3 ) , MST2 (human) ( 3 ) , OGT (human) ( 4 )
Treatments:
stiff ECM substrate ( 3 ) , TGF-beta ( 1 ) , U73122 ( 3 )

Downstream Regulation
Effects of modification on LATS2:
activity, induced ( 5 ) , enzymatic activity, induced ( 3 ) , phosphorylation ( 3 )
Effects of modification on biological processes:
carcinogenesis, inhibited ( 3 ) , cell growth, inhibited ( 3 ) , signaling pathway regulation ( 5 , 6 )

References 

1

Fujibayashi E, et al. (2022) LATS kinases and SLUG regulate the transition to advanced stage in aggressive oral cancer cells. Sci Rep 12, 12363
35859006   Curated Info

2

Wang Y, et al. (2022) FRK inhibits glioblastoma progression via phosphorylating YAP and inducing its ubiquitylation and degradation by Siah1. Neuro Oncol 24
35723276   Curated Info

3

Li J, et al. (2021) Mechanosensitive turnover of phosphoribosyl pyrophosphate synthetases regulates nucleotide metabolism. Cell Death Differ
34465890   Curated Info

4

Kim E, et al. (2020) -GlcNAcylation on LATS2 disrupts the Hippo pathway by inhibiting its activity. Proc Natl Acad Sci U S A 117, 14259-14269
32513743   Curated Info

5

Nozaki M, et al. (2019) LATS1/2 kinases trigger self-renewal of cancer stem cells in aggressive oral cancer. Oncotarget 10, 1014-1030
30800215   Curated Info

6

Mohseni M, et al. (2014) A genetic screen identifies an LKB1-MARK signalling axis controlling the Hippo-YAP pathway. Nat Cell Biol 16, 108-17
24362629   Curated Info