Ser515
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Home > Phosphorylation Site Page: > Ser515  -  NHE3 (rabbit)

Site Information
NFDRRFLsKLLMRQs   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 31839901

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
Akt1 (human) ( 1 )
Kinases, in vitro:
Akt1 (human) ( 1 )
Treatments:
Akt_inhibitor_VIII ( 1 )

Downstream Regulation
Effects of modification on NHE3:
activity, induced ( 1 ) , intracellular localization ( 1 ) , molecular association, regulation ( 1 )
Induce interaction with:
Ezrin (human) ( 1 )

References 

1

Singh V, et al. (2014) AKT and GSK-3 Are Necessary for Direct Ezrin Binding to NHE3 as Part of a C-terminal Stimulatory Complex: ROLE OF A NOVEL SER-RICH NHE3 C-TERMINAL MOTIF IN NHE3 ACTIVITY AND TRAFFICKING. J Biol Chem 289, 5449-61
24398676   Curated Info