Ser244
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage PhosphoSitePlus®
Powered by Cell Signaling Technology
Home > Phosphorylation Site Page: > Ser244  -  KIF20A (human)

Site Information
LSTsLkRsVyIEsRI   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 459830

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mass spectrometry ( 2 , 3 , 4 , 5 , 6 ) , mutation of modification site ( 1 ) , western blotting ( 1 )
Disease tissue studied:
breast cancer ( 3 ) , breast cancer, surrounding tissue ( 2 ) , breast cancer, triple negative ( 3 )
Relevant cell line - cell type - tissue:
breast ( 2 , 3 ) , HeLa (cervical) ( 1 , 6 ) , HeLa S3 (cervical) ( 4 , 5 ) , HeLa S3 (cervical) [PLK1 (human), knockdown, Tet-inducible PLK1 siRNA] ( 4 )

Upstream Regulation
Kinases, in vitro:
NEK6 (human) ( 1 )
Treatments:
ZK-Thiazolidinone ( 4 )

Downstream Regulation
Effects of modification on KIF20A:
activity, inhibited ( 1 ) , intracellular localization ( 1 )
Effects of modification on biological processes:
chromatin organization, altered ( 1 )

References 

1

Cullati SN, Kabeche L, Kettenbach AN, Gerber SA (2017) A bifurcated signaling cascade of NIMA-related kinases controls distinct kinesins in anaphase. J Cell Biol 216, 2339-2354
28630147   Curated Info

2

Mertins P, et al. (2016) Proteogenomics connects somatic mutations to signalling in breast cancer. Nature 534, 55-62
27251275   Curated Info

3

Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704
24719451   Curated Info

4

Santamaria A, et al. (2011) The Plk1-dependent phosphoproteome of the early mitotic spindle. Mol Cell Proteomics 10, M110.004457
20860994   Curated Info

5

Malik R, et al. (2009) Quantitative analysis of the human spindle phosphoproteome at distinct mitotic stages. J Proteome Res 8, 4553-63
19691289   Curated Info

6

Nousiainen M, et al. (2006) Phosphoproteome analysis of the human mitotic spindle. Proc Natl Acad Sci U S A 103, 5391-6
16565220   Curated Info