Ser326

Site Information
PsLNtGsssPRGVEE SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 3174521

In vivo Characterization
Methods used to characterize site in vivo:	mass spectrometry ( 1 , 2 , 3 , 4 , 6 , 7 , 8 , 9 , 10 , 11 )
Disease tissue studied:	lung cancer ( 1 , 9 ) , non-small cell lung adenocarcinoma ( 1 )
Relevant cell line - cell type - tissue:	293E (epithelial) ( 6 ) , CL1-0 (pulmonary) ( 9 ) , CL1-1 (pulmonary) ( 9 ) , CL1-2 (pulmonary) ( 9 ) , CL1-5 (pulmonary) ( 9 ) , HeLa (cervical) ( 2 , 11 ) , HeLa S3 (cervical) ( 7 ) , HUES-7 ('stem, embryonic') ( 10 ) , HUES-9 ('stem, embryonic') ( 8 ) , K562 (erythroid) ( 4 ) , liver ( 3 ) , PC9 (pulmonary) ( 1 )

Upstream Regulation
Treatments:	metastatic potential ( 9 )

References
1	Tsai CF, et al. (2015) Large-scale determination of absolute phosphorylation stoichiometries in human cells by motif-targeting quantitative proteomics. Nat Commun 6, 6622 25814448 Curated Info
2	Sharma K, et al. (2014) Ultradeep human phosphoproteome reveals a distinct regulatory nature of Tyr and Ser/Thr-based signaling. Cell Rep 8, 1583-94 25159151 Curated Info
3	Bian Y, et al. (2014) An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J Proteomics 96, 253-62 24275569 Curated Info
4	Zhou H, et al. (2013) Toward a comprehensive characterization of a human cancer cell phosphoproteome. J Proteome Res 12, 260-71 23186163 Curated Info
5	Beli P, et al. (2012) Proteomic Investigations Reveal a Role for RNA Processing Factor THRAP3 in the DNA Damage Response. Mol Cell 46, 212-25 22424773 Curated Info
6	Hsu PP, et al. (2011) The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling. Science 332, 1317-22 21659604 Curated Info
7	Santamaria A, et al. (2011) The Plk1-dependent phosphoproteome of the early mitotic spindle. Mol Cell Proteomics 10, M110.004457 20860994 Curated Info
8	Rigbolt KT, et al. (2011) System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. Sci Signal 4, rs3 21406692 Curated Info
9	Wang YT, et al. (2010) An informatics-assisted label-free quantitation strategy that depicts phosphoproteomic profiles in lung cancer cell invasion. J Proteome Res 9, 5582-97 20815410 Curated Info
10	Van Hoof D, et al. (2009) Phosphorylation dynamics during early differentiation of human embryonic stem cells. Cell Stem Cell 5, 214-26 19664995 Curated Info
11	Dephoure N, et al. (2008) A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A 105, 10762-7 18669648 Curated Info