Tyr40
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Home > Phosphorylation Site Page: > Tyr40  -  Etk (human)

Site Information
LTKTNLSyYEYDKMK   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448066

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 5 ) , mutation of modification site ( 5 ) , phospho-antibody ( 1 , 2 , 3 , 4 , 5 ) , western blotting ( 2 , 3 , 4 , 5 )
Disease tissue studied:
lung cancer ( 4 ) , small-cell lung cancer ( 4 )
Relevant cell line - cell type - tissue:
'stem, neural' ( 3 ) , 293 (epithelial) ( 5 ) , CHO (fibroblast) [EphB1 (human), transfection] ( 5 ) , endothelial ( 2 ) , hUCB-MSCs ( 1 ) , HUVEC (endothelial) ( 5 ) , NCI-H69 (pulmonary) ( 4 ) , stem ( 2 )

Upstream Regulation
Regulatory protein:
CD133 (human) ( 3 )
Treatments:
fibronectin ( 5 )

Downstream Regulation
Effects of modification on Etk:
enzymatic activity, induced ( 5 ) , intracellular localization ( 5 ) , molecular association, regulation ( 5 )
Effects of modification on biological processes:
cell motility, altered ( 5 ) , cytoskeletal reorganization ( 5 )
Induce interaction with:
FAK (human) ( 5 )

References 

1

Han KH, et al. (2017) Protein profiling and angiogenic effect of hypoxia-cultured human umbilical cord blood-derived mesenchymal stem cells in hindlimb ischemia. Tissue Cell 49, 680-690
28958480   Curated Info

2

Burgett ME, et al. (2016) Direct contact with perivascular tumor cells enhances integrin αvβ3 signaling and migration of endothelial cells. Oncotarget 7, 43852-43867
27270311   Curated Info

3

Guryanova OA, et al. (2011) Nonreceptor tyrosine kinase BMX maintains self-renewal and tumorigenic potential of glioblastoma stem cells by activating STAT3. Cancer Cell 19, 498-511
21481791   Curated Info

4

Guo L, Zhou Y, Sun Y, Zhang F (2010) Non-receptor tyrosine kinase Etk regulation of drug resistance in small-cell lung cancer. Eur J Cancer 46, 636-41
20004564   Curated Info

5

Chen R, et al. (2001) Regulation of the PH-domain-containing tyrosine kinase Etk by focal adhesion kinase through the FERM domain. Nat Cell Biol 3, 439-44
11331870   Curated Info