Lys48
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Home > Acetylation Site Page: > Lys48  -  LKB1 (human)

Site Information
KRAkLIGkYLMGDLL   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 3173806

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 2 ) , mass spectrometry ( 2 ) , mutation of modification site ( 2 ) , western blotting ( 2 )
Relevant cell line - cell type - tissue:
adipose tissue ( 2 ) , HEK293T (epithelial) ( 2 )

Upstream Regulation
Treatments:
siRNA ( 2 )

Downstream Regulation
Effects of modification on LKB1:
enzymatic activity, inhibited ( 2 ) , intracellular localization ( 2 ) , molecular association, regulation ( 2 ) , phosphorylation ( 2 )
Inhibit interaction with:
STRAD (human) ( 2 )

References 

1

Zubiete-Franco I, et al. (2019) SUMOylation regulates LKB1 localization and its oncogenic activity in liver cancer. EBioMedicine 40, 406-421
30594553   Curated Info

2

Lan F, Cacicedo JM, Ruderman N, Ido Y (2008) SIRT1 modulation of the acetylation status, cytosolic localization, and activity of LKB1. Possible role in AMP-activated protein kinase activation. J Biol Chem 283, 27628-35
18687677   Curated Info