Lys97
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Home > Acetylation Site Page: > Lys97  -  LKB1 (human)

Site Information
NGEANVkkEIQLLRR   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 3173802

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 2 ) , mutation of modification site ( 1 )
Relevant cell line - cell type - tissue:

Downstream Regulation
Effects of modification on LKB1:
enzymatic activity, inhibited ( 1 )
Induce interaction with:
Other ( 1 )

References 

1

Calamaras TD, et al. (2012) Post-translational modification of serine/threonine kinase LKB1 via Adduction of the Reactive Lipid Species 4-Hydroxy-trans-2-nonenal (HNE) at lysine residue 97 directly inhibits kinase activity. J Biol Chem 287, 42400-6
23086944   Curated Info

2

Lan F, Cacicedo JM, Ruderman N, Ido Y (2008) SIRT1 modulation of the acetylation status, cytosolic localization, and activity of LKB1. Possible role in AMP-activated protein kinase activation. J Biol Chem 283, 27628-35
18687677   Curated Info