Ser497
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Home > Phosphorylation Site Page: > Ser497  -  perilipin 1 (human)

Site Information
EKPKRRVsDsFFRPs   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 459628

In vivo Characterization
Methods used to characterize site in vivo:
immunoassay ( 8 ) , immunoprecipitation ( 1 ) , mass spectrometry ( 2 , 3 , 4 , 5 , 9 ) , phospho-antibody ( 1 , 7 , 8 ) , western blotting ( 1 )
Disease tissue studied:
breast cancer ( 3 ) , breast ductal carcinoma ( 3 ) , HER2 positive breast cancer ( 2 ) , luminal A breast cancer ( 2 ) , luminal B breast cancer ( 2 ) , breast cancer, surrounding tissue ( 2 ) , breast cancer, triple negative ( 2 , 3 ) , ovarian cancer ( 3 ) , pancreatic ductal adenocarcinoma ( 5 )
Relevant cell line - cell type - tissue:
'muscle, skeletal' ( 9 ) , 'pancreatic, ductal'-pancreas ( 5 ) , 293 (epithelial) ( 8 ) , breast ( 2 , 3 ) , liver ( 4 ) , ovary ( 3 ) , preadipocyte ( 7 ) , stem-adipose tissue ( 1 )

Upstream Regulation
Regulatory protein:
OPA1 (human) ( 1 )
Treatments:
colforsin ( 7 ) , IBMX ( 7 ) , isoproterenol ( 1 , 8 ) , Lys-gamma3-MSH ( 7 )

Downstream Regulation
Effects of modification on perilipin 1:
intracellular localization ( 1 )

References 

1

Rogne M, et al. (2018) OPA1-anchored PKA phosphorylates perilipin 1 on S522 and S497 in adipocytes differentiated from human adipose stem cells. Mol Biol Cell, mbcE17090538
29688805   Curated Info

2

Mertins P, et al. (2016) Proteogenomics connects somatic mutations to signalling in breast cancer. Nature 534, 55-62
27251275   Curated Info

3

Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704
24719451   Curated Info

4

Bian Y, et al. (2014) An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J Proteomics 96, 253-62
24275569   Curated Info

5

Britton D, et al. (2014) Quantification of pancreatic cancer proteome and phosphorylome: indicates molecular events likely contributing to cancer and activity of drug targets. PLoS One 9, e90948
24670416   Curated Info

6

Shiromizu T, et al. (2013) Identification of missing proteins in the neXtProt database and unregistered phosphopeptides in the PhosphoSitePlus database as part of the Chromosome-centric Human Proteome Project. J Proteome Res 12, 2414-21
23312004   Curated Info

7

McDonough PM, et al. (2013) Differential Phosphorylation of Perilipin 1A at the Initiation of Lipolysis Revealed by Novel Monoclonal Antibodies and High Content Analysis. PLoS One 8, e55511
23405163   Curated Info

8

Orlicky DJ, Monks J, Stefanski AL, McManaman JL (2013) Dynamics and molecular determinants of cytoplasmic lipid droplet clustering and dispersion. PLoS One 8, e66837
23825572   Curated Info

9

Lundby A, et al. (2012) Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. Nat Commun 3, 876
22673903   Curated Info