Thr1797
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Home > Phosphorylation Site Page: > Thr1797  -  KI-67 (human)

Site Information
GEEkDINtFLGtPVQ   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 3148173

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 1 , 2 , 3 , 4 , 5 , 6 )
Disease tissue studied:
lung cancer ( 1 , 6 ) , non-small cell lung cancer ( 1 , 6 )
Relevant cell line - cell type - tissue:
Flp-In T-Rex-293 (epithelial) [PRKD1 (human), genetic knockin] ( 2 ) , Flp-In T-Rex-293 (epithelial) ( 2 ) , HCC1359 (pulmonary) ( 1 ) , HCC2279 (pulmonary) ( 1 ) , HCC366 (pulmonary) ( 1 ) , HCC4006 (pulmonary) ( 1 ) , HCC78 (pulmonary) ( 1 ) , HeLa (cervical) ( 4 , 5 ) , HeLa S3 (cervical) ( 3 ) , HOP62 (pulmonary) ( 1 ) , lung ( 6 ) , NCI-H2172 (pulmonary) ( 1 ) , NCI-H322 (pulmonary) ( 1 )

Upstream Regulation
Treatments:
ZK-Thiazolidinone ( 3 )

References 

1

Klammer M, et al. (2012) Phosphosignature predicts dasatinib response in non-small cell lung cancer. Mol Cell Proteomics 11, 651-68
22617229   Curated Info

2

Franz-Wachtel M, et al. (2012) Global detection of protein kinase D-dependent phosphorylation events in nocodazole-treated human cells. Mol Cell Proteomics 11, 160-70
22496350   Curated Info

3

Santamaria A, et al. (2011) The Plk1-dependent phosphoproteome of the early mitotic spindle. Mol Cell Proteomics 10, M110.004457
20860994   Curated Info

4

Kettenbach AN, et al. (2011) Quantitative phosphoproteomics identifies substrates and functional modules of aurora and polo-like kinase activities in mitotic cells. Sci Signal 4, rs5
21712546   Curated Info

5

Chen RQ, et al. (2009) CDC25B mediates rapamycin-induced oncogenic responses in cancer cells. Cancer Res 69, 2663-8
19276368   Curated Info

6

Rikova K (2008) CST Curation Set: 5559; Year: 2008; Biosample/Treatment: tissue, lung/untreated; Disease: non-small cell lung cancer; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

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