Lys953
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Home > Sumoylation Site Page: > Lys953  -  MCR (human)

Site Information
FRESHALkVEFPAML   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 3144807

In vivo Characterization
Methods used to characterize site in vivo:
electrophoretic mobility shift ( 2 , 3 ) , mutation of modification site ( 1 , 2 , 3 ) , western blotting ( 2 , 3 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Treatments:
aldosterone ( 2 )

Downstream Regulation
Effects of modification on biological processes:
transcription, induced ( 2 ) , transcription, inhibited ( 3 )

References 

1

Faresse N, Vitagliano JJ, Staub O (2012) Differential ubiquitylation of the mineralocorticoid receptor is regulated by phosphorylation. FASEB J 26, 4373-82
22798426   Curated Info

2

Yokota K, et al. (2007) Coactivation of the N-terminal transactivation of mineralocorticoid receptor by Ubc9. J Biol Chem 282, 1998-2010
17105732   Curated Info

3

Tallec LP, et al. (2003) Protein inhibitor of activated signal transducer and activator of transcription 1 interacts with the N-terminal domain of mineralocorticoid receptor and represses its transcriptional activity: implication of small ubiquitin-related modifier 1 modification. Mol Endocrinol 17, 2529-42
14500761   Curated Info