Ser266
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Home > Phosphorylation Site Page: > Ser266  -  EWS (human)

Site Information
SSYGQQSsFRQDHPs   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448028

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 1 ) , electrophoretic mobility shift ( 1 ) , mutation of modification site ( 1 )
Relevant cell line - cell type - tissue:
3T3 (fibroblast) [SHP-2 (mouse), homozygous knockout] ( 1 ) , COS (fibroblast) ( 1 ) , HEK293T (epithelial) ( 1 ) , HeLa (cervical) ( 1 )

Upstream Regulation
Kinases, in vitro:
PKCA (human) ( 2 )

Downstream Regulation
Effects of modification on EWS:
intracellular localization ( 1 )
Effects of modification on biological processes:
transcription, induced ( 1 )

References 

1

Olsen RJ, Hinrichs SH (2001) Phosphorylation of the EWS IQ domain regulates transcriptional activity of the EWS/ATF1 and EWS/FLI1 fusion proteins. Oncogene 20, 1756-64
11313922   Curated Info

2

Deloulme JC, Prichard L, Delattre O, Storm DR (1997) The prooncoprotein EWS binds calmodulin and is phosphorylated by protein kinase C through an IQ domain. J Biol Chem 272, 27369-77
9341188   Curated Info

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