Thr172
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Home > Phosphorylation Site Page: > Thr172  -  AMPKA2 (human)

Site Information
sDGEFLRtsCGsPNy   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448026
Available spectra:  1 CST
Associated spectra:  1 CST

In vivo Characterization
Methods used to characterize site in vivo:
[32P] ATP in vitro ( 2 ) , flow cytometry ( 3 ) , immunoprecipitation ( 2 , 4 , 8 , 11 , 13 , 41 ) , mass spectrometry ( 2 , 7 , 21 , 22 , 27 , 29 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 40 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 53 , 54 , 55 , 57 , 58 , 59 , 60 , 67 ) , mutation of modification site ( 2 , 4 , 6 , 12 , 13 , 41 , 72 ) , phospho-antibody ( 2 , 3 , 4 , 5 , 6 , 8 , 9 , 11 , 12 , 13 , 16 , 17 , 18 , 25 , 26 , 41 , 51 , 52 , 56 , 61 , 62 , 63 , 65 , 66 , 68 , 69 , 70 , 73 , 74 , 75 ) , western blotting ( 2 , 3 , 4 , 5 , 6 , 8 , 9 , 11 , 12 , 13 , 16 , 17 , 18 , 25 , 26 , 41 , 51 , 52 , 56 , 61 , 62 , 63 , 65 , 66 , 68 , 69 , 70 )
Disease tissue studied:
bone cancer ( 41 , 63 ) , brain cancer ( 12 ) , glioblastoma multiforme ( 12 ) , glioma ( 12 ) , breast cancer ( 11 ) , breast ductal carcinoma ( 11 ) , HER2 positive breast cancer ( 7 ) , luminal A breast cancer ( 7 ) , luminal B breast cancer ( 7 ) , breast cancer, triple negative ( 7 , 11 ) , cervical cancer ( 26 ) , cervical adenocarcinoma ( 26 ) , gastric cancer ( 40 , 45 ) , gastric carcinoma ( 40 , 45 ) , leukemia ( 6 ) , T cell leukemia ( 6 ) , liver cancer ( 17 , 61 ) , hepatocellular carcinoma ( 17 ) , lung cancer ( 8 , 16 , 21 , 22 , 53 , 54 , 55 ) , non-small cell lung cancer ( 8 , 16 , 21 , 53 , 54 , 55 ) , non-small cell lung adenocarcinoma ( 8 , 16 , 21 , 22 ) , non-small cell squamous cell lung carcinoma ( 22 ) , prostate cancer ( 5 )
Relevant cell line - cell type - tissue:
'muscle, skeletal' ( 9 , 68 , 69 , 74 , 75 ) , 'muscle, smooth'-thoracic aorta ( 51 ) , 293 (epithelial) [IRS1 (human)] ( 66 ) , 293 (epithelial) ( 18 , 56 , 61 , 72 ) , 3T3 (fibroblast) ( 4 , 25 ) , A549 (pulmonary) ( 8 , 16 , 21 ) , ARPE19 (retinal) ( 62 ) , BAEC (endothelial) ( 18 ) , breast ( 7 ) , C2C12 (myoblast) ( 56 ) , C4-2 (prostate cell) ( 5 ) , C4-2B (prostate cell) ( 5 ) , COS7 (fibroblast) ( 2 ) , HCC1419 (breast cell) ( 11 ) , HCC15 (pulmonary) ( 22 ) , HCC1806 (breast cell) ( 11 ) , HEK293T (epithelial) ( 4 , 13 , 25 , 41 ) , HeLa (cervical) ( 4 , 8 , 13 , 52 , 57 , 58 , 60 ) , HeLa S3 (cervical) ( 26 ) , HepG2 (hepatic) ( 61 , 73 ) , Huh7 (hepatic) ( 17 ) , Jurkat (T lymphocyte) ( 6 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 42 , 46 , 47 , 48 , 49 , 50 , 67 ) , K562 (erythroid) ( 27 ) , L6 (myoblast) ( 66 ) , LNCaP (prostate cell) ( 5 ) , LOU-NH91 (squamous) ( 22 ) , lung ( 21 , 22 , 53 , 54 , 55 ) , lymphocyte-blood ( 3 ) , MDA-MB-435S (breast cell) ( 59 ) , MDCK (epithelial) ( 18 ) , MEF (fibroblast) ( 8 , 18 ) , mIMCD-3 (epithelial) ( 18 ) , MKN-45 (gastric) ( 40 ) , MMDD1 (renal) ( 18 ) , MV4-11 (macrophage) ( 59 ) , NCI-H1355 (pulmonary) ( 21 ) , NCI-H1703 (squamous) ( 22 ) , NCI-H1792 (pulmonary) ( 21 ) , NCI-H2073 (pulmonary) ( 22 ) , NCI-H23 (pulmonary) ( 21 ) , NCI-H2342 (pulmonary) ( 22 ) , NCI-H441 (pulmonary) ( 21 ) , oocyte ( 65 ) , ovarian ( 65 ) , PAE (endothelial) ( 70 ) , SKBr3 (breast cell) ( 11 ) , stomach ( 45 ) , T98G (glial) ( 12 ) , U2OS (bone cell) ( 41 , 63 )

Upstream Regulation
Regulatory protein:
CENTG1 (human) ( 8 ) , IL6 (mouse) ( 9 ) , LKB1 (human) ( 8 , 61 ) , Myc (human) ( 16 ) , SIRT1 (human) ( 61 ) , TAB1 (human) ( 52 )
Putative in vivo kinases:
TAK1 (human) ( 52 )
Kinases, in vitro:
CAMKK2 (human) ( 2 ) , TAK1 (human) ( 52 )
Phosphatases, in vitro:
PPP2CA (human) ( 64 )
Treatments:
2-deoxyglucose ( 51 ) , 2-hydroxyestradiol ( 70 ) , 2-methoxyestradiol ( 70 ) , 5-iodotubercidin ( 70 ) , A-769662 ( 18 ) , ABT ( 70 ) , acadesine ( 11 , 25 , 30 , 51 , 61 ) , angiotensin_2 ( 28 ) , anti-CD3 ( 6 ) , bisindolylmaleimide ( 70 ) , CCCP ( 66 ) , cobalt ( 66 ) , compound_C ( 18 , 30 , 51 , 65 , 70 ) , estradiol ( 70 ) , exercise ( 9 , 69 , 74 , 75 ) , exercise training ( 69 ) , faslodex ( 70 ) , glucagon ( 17 ) , glucose ( 61 , 73 ) , glucose_starvation ( 41 , 56 , 63 , 66 ) , Go_6983 ( 70 ) , H-89 ( 17 ) , H2O2 ( 52 , 62 , 66 ) , hypoxia ( 66 ) , insulin ( 17 , 66 ) , ischemia ( 30 ) , low_glucose ( 12 ) , LY294002 ( 70 ) , metformin ( 17 , 25 , 26 , 51 , 65 , 73 ) , nicotinamide ( 61 ) , nicotine ( 28 ) , oligomycin ( 66 ) , ONOO(-) ( 26 ) , PD98059 ( 70 ) , PP2 ( 70 ) , resveratrol ( 39 , 61 ) , Ro_41-0960 ( 70 ) , S17834 ( 61 ) , salinomycin ( 5 ) , splitomicin ( 61 ) , TNF ( 4 )

Downstream Regulation
Effects of modification on AMPKA2:
enzymatic activity, induced ( 25 , 26 , 71 , 74 ) , phosphorylation ( 25 )

References 

1

Chen Z, et al. (2019) Global phosphoproteomic analysis reveals ARMC10 as an AMPK substrate that regulates mitochondrial dynamics. Nat Commun 10, 104
30631047   Curated Info

2

Nakanishi A, et al. (2017) AMP-activated protein kinase-mediated feedback phosphorylation controls the Ca2+/calmodulin (CaM) dependence of Ca2+/CaM-dependent protein kinase kinase β. J Biol Chem 292, 19804-19813
28974582   Curated Info

3

Craveiro M, et al. (2017) Resveratrol stimulates the metabolic reprogramming of human CD4+ T cells to enhance effector function. Sci Signal 10
29042482   Curated Info

4

Yamada E, et al. (2016) Fyn phosphorylates AMPK to inhibit AMPK activity and AMP-dependent activation of autophagy. Oncotarget 7, 74612-74629
27626315   Curated Info

5

Mirkheshti N, et al. (2016) Dual targeting of androgen receptor and mTORC1 by salinomycin in prostate cancer. Oncotarget 7, 62240-62254
27557496   Curated Info

6

Corrado M, et al. (2016) Macroautophagy inhibition maintains fragmented mitochondria to foster T cell receptor-dependent apoptosis. EMBO J 35, 1793-809
27390127   Curated Info

7

Mertins P, et al. (2016) Proteogenomics connects somatic mutations to signalling in breast cancer. Nature 534, 55-62
27251275   Curated Info

8

Zhang S, et al. (2016) Fyn-phosphorylated PIKE-A binds and inhibits AMPK signaling, blocking its tumor suppressive activity. Cell Death Differ 23, 52-63
26001218   Curated Info

9

Gudiksen A, et al. (2016) Lack of Skeletal Muscle IL-6 Affects Pyruvate Dehydrogenase Activity at Rest and during Prolonged Exercise. PLoS One 11, e0156460
27327080   Curated Info

10

Agarwal S, Bell CM, Rothbart SB, Moran RG (2015) AMP-activated Protein Kinase (AMPK) Control of mTORC1 Is p53- and TSC2-independent in Pemetrexed-treated Carcinoma Cells. J Biol Chem 290, 27473-86
26391395   Curated Info

11

Jhaveri TZ, et al. (2015) AMP-activated kinase (AMPK) regulates activity of HER2 and EGFR in breast cancer. Oncotarget 6, 14754-65
26143491   Curated Info

12

Ansari KI, et al. (2015) Glucose-Based Regulation of miR-451/AMPK Signaling Depends on the OCT1 Transcription Factor. Cell Rep 11, 902-9
25937278   Curated Info

13

Ber Y, et al. (2015) DAPK2 is a novel regulator of mTORC1 activity and autophagy. Cell Death Differ 22, 465-75
25361081   Curated Info

14

Kalsen A, et al. (2014) Effect of inhaled terbutaline on substrate utilization and 300-kcal time trial performance. J Appl Physiol (1985) 117, 1180-7
25257871   Curated Info

15

Yun H, et al. (2014) AMP-activated protein kinase mediates the antioxidant effects of resveratrol through regulation of the transcription factor FoxO1. FEBS J 281, 4421-38
25065674   Curated Info

16

Edmunds LR, et al. (2014) c-Myc Programs Fatty Acid Metabolism and Dictates Acetyl-CoA Abundance and Fate. J Biol Chem 289, 25382-92
25053415   Curated Info

17

Aw DK, Sinha RA, Xie SY, Yen PM (2014) Differential AMPK phosphorylation by glucagon and metformin regulates insulin signaling in human hepatic cells. Biochem Biophys Res Commun 447, 569-73
24735537   Curated Info

18

Fraser SA, et al. (2014) Activation of AMPK reduces the co-transporter activity of NKCC1. Mol Membr Biol 31, 95-102
24702155   Curated Info

19

Treebak JT, et al. (2014) Acute exercise and physiological insulin induce distinct phosphorylation signatures on TBC1D1 and TBC1D4 proteins in human skeletal muscle. J Physiol 592, 351-75
24247980   Curated Info

20

Lau AW, Liu P, Inuzuka H, Gao D (2014) SIRT1 phosphorylation by AMP-activated protein kinase regulates p53 acetylation. Am J Cancer Res 4, 245-55
24959379   Curated Info

21

Rikova K, Hall B (2013) CST Curation Set: 20736, 21163, 30158, 30159, 30160; Year: 2013; Biosample/Treatment: cell line, A549, H1355, H23, H441, H1792; Disease: -; TMT: Y; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY, p[ST], RXXp[ST], pSQ, p[ST]QG, LXRXXp[ST], p[ST]P
Curated Info

22

Rikova K, Hall B (2013) CST Curation Set: 20739, 21166, 30167, 30168, 30169; Year: 2013; Biosample/Treatment: cell line, H2342, H2073, Lou-NH91, HCC15, H1703; Disease: -; TMT: Y; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY, p[ST], RXXp[ST], pSQ, p[ST]QG, LXRXXp[ST], p[ST]P
Curated Info

23

Yi G, et al. (2013) Low concentration of metformin induces a p53-dependent senescence in hepatoma cells via activation of the AMPK pathway. Int J Oncol 43, 1503-10
23982736   Curated Info

24

Alzamora R, et al. (2013) AMP-activated protein kinase regulates the vacuolar H+-ATPase via direct phosphorylation of the A subunit (ATP6V1A) in the kidney. Am J Physiol Renal Physiol 305, F943-56
23863464   Curated Info

25

Um JH, et al. (2013) Metabolic sensor AMPK directly phosphorylates RAG1 protein and regulates V(D)J recombination. Proc Natl Acad Sci U S A 110, 9873-8
23716691   Curated Info

26

Zhu H, et al. (2013) Phosphorylation of serine 399 in LKB1 protein short form by protein kinase Cζ is required for its nucleocytoplasmic transport and consequent AMP-activated protein kinase (AMPK) activation. J Biol Chem 288, 16495-505
23612973   Curated Info

27

Zhou H, et al. (2013) Toward a comprehensive characterization of a human cancer cell phosphoproteome. J Proteome Res 12, 260-71
23186163   Curated Info

28

Wang S, et al. (2012) Activation of AMP-activated protein kinase α2 by nicotine instigates formation of abdominal aortic aneurysms in mice in vivo. Nat Med 18, 902-10
22561688   Curated Info

29

Stokes MP, et al. (2012) PTMScan Direct: Identification and Quantification of Peptides from Critical Signaling Proteins by Immunoaffinity Enrichment Coupled with LC-MS/MS. Mol Cell Proteomics 11, 187-201
22322096   Curated Info

30

Oliveira SM, et al. (2012) AMP-activated protein kinase phosphorylates cardiac troponin I and alters contractility of murine ventricular myocytes. Circ Res 110, 1192-201
22456184   Curated Info

31

Guo A (2012) CST Curation Set: 13982; Year: 2012; Biosample/Treatment: cell line, Jurkat/calyculin_A & pervanadate; Disease: T cell leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[STY]
Curated Info

32

Mulhern D (2012) CST Curation Set: 13939; Year: 2012; Biosample/Treatment: cell line, Jurkat/calyculin_A & pervanadate; Disease: T cell leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[STY]
Curated Info

33

Mulhern D (2012) CST Curation Set: 13827; Year: 2012; Biosample/Treatment: cell line, Jurkat/calyculin_A & pervanadate; Disease: T cell leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: (K/R)XpSX(K/R)
Curated Info

34

Mulhern D (2012) CST Curation Set: 13829; Year: 2012; Biosample/Treatment: cell line, Jurkat/calyculin_A & pervanadate; Disease: T cell leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: (K/R)XpSX(K/R)
Curated Info

35

Mulhern D (2012) CST Curation Set: 13107; Year: 2012; Biosample/Treatment: cell line, Jurkat/calyculin_A & pervanadate; Disease: T cell leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[STY])
Curated Info

36

Mulhern D (2012) CST Curation Set: 13108; Year: 2012; Biosample/Treatment: cell line, Jurkat/calyculin_A & pervanadate; Disease: T cell leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[STY])
Curated Info

37

Mulhern D (2012) CST Curation Set: 13109; Year: 2012; Biosample/Treatment: cell line, Jurkat/calyculin_A & pervanadate; Disease: T cell leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[STY]
Curated Info

38

Mulhern D (2012) CST Curation Set: 13112; Year: 2012; Biosample/Treatment: cell line, Jurkat/calyculin_A & pervanadate; Disease: T cell leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[STY])
Curated Info

39

Park SJ, et al. (2012) Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases. Cell 148, 421-33
22304913   Curated Info

40

Mulhern D (2012) CST Curation Set: 13405; Year: 2012; Biosample/Treatment: cell line, MKN-45/untreated; Disease: gastric carcinoma; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[STY]
Curated Info

41

Banko MR, et al. (2011) Chemical genetic screen for AMPKα2 substrates uncovers a network of proteins involved in mitosis. Mol Cell 44, 878-92
22137581   Curated Info

42

Mulhern D (2011) CST Curation Set: 13106; Year: 2011; Biosample/Treatment: cell line, Jurkat/calyculin_A & pervanadate; Disease: T cell leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[STY])
Curated Info

43

Rikova K (2011) CST Curation Set: 13114; Year: 2011; Biosample/Treatment: cell line, MGH-2/unknown; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[STY])
Curated Info

44

Rikova K (2011) CST Curation Set: 13122; Year: 2011; Biosample/Treatment: cell line, MGH-10/unknown; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[STY])
Curated Info

45

Rikova K (2011) CST Curation Set: 12176; Year: 2011; Biosample/Treatment: tissue, gastrointestinal tract/untreated; Disease: gastric carcinoma; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

46

Guo A (2011) CST Curation Set: 11884; Year: 2011; Biosample/Treatment: cell line, Jurkat/calyculin_A & pervanadate; Disease: T cell leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[ST]P
Curated Info

47

Guo A (2011) CST Curation Set: 11890; Year: 2011; Biosample/Treatment: cell line, Jurkat/calyculin_A & pervanadate; Disease: T cell leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[STY]
Curated Info

48

Guo A (2011) CST Curation Set: 11891; Year: 2011; Biosample/Treatment: cell line, Jurkat/calyculin_A & pervanadate; Disease: T cell leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[STY]
Curated Info

49

Guo A (2011) CST Curation Set: 11892; Year: 2011; Biosample/Treatment: cell line, Jurkat/calyculin_A & pervanadate; Disease: T cell leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[STY]
Curated Info

50

Guo A (2011) CST Curation Set: 11893; Year: 2011; Biosample/Treatment: cell line, Jurkat/calyculin_A & pervanadate; Disease: T cell leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[STY]
Curated Info

51

Vigetti D, et al. (2011) Hyaluronan Synthesis Is Inhibited by Adenosine Monophosphate-activated Protein Kinase through the Regulation of HAS2 Activity in Human Aortic Smooth Muscle Cells. J Biol Chem 286, 7917-24
21228273   Curated Info

52

Scholz R, et al. (2010) Autoactivation of transforming growth factor beta-activated kinase 1 is a sequential bimolecular process. J Biol Chem 285, 25753-66
20538596   Curated Info

53

Rikova K (2010) CST Curation Set: 9452; Year: 2010; Biosample/Treatment: tissue, lung/untreated; Disease: non-small cell lung cancer; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[STY])
Curated Info

54

Rikova K (2010) CST Curation Set: 9456; Year: 2010; Biosample/Treatment: tissue, lung/untreated; Disease: non-small cell lung cancer; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[STY])
Curated Info

55

Rikova K (2010) CST Curation Set: 9450; Year: 2010; Biosample/Treatment: tissue, lung/untreated; Disease: non-small cell lung cancer; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[STY])
Curated Info

56

Kim JH, et al. (2010) Phospholipase D1 mediates AMP-activated protein kinase signaling for glucose uptake. PLoS One 5, e9600
20231899   Curated Info

57

Zhou J (2009) CST Curation Set: 7592; Year: 2009; Biosample/Treatment: cell line, HeLa/untreated; Disease: cervical adenocarcinoma; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[ST]P
Curated Info

58

Zhou J (2009) CST Curation Set: 7591; Year: 2009; Biosample/Treatment: cell line, HeLa/untreated; Disease: cervical adenocarcinoma; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[ST]P
Curated Info

59

Oppermann FS, et al. (2009) Large-scale proteomics analysis of the human kinome. Mol Cell Proteomics 8, 1751-64
19369195   Curated Info

60

Chen RQ, et al. (2009) CDC25B mediates rapamycin-induced oncogenic responses in cancer cells. Cancer Res 69, 2663-8
19276368   Curated Info

61

Hou X, et al. (2008) SIRT1 regulates hepatocyte lipid metabolism through activating AMP-activated protein kinase. J Biol Chem 283, 20015-26
18482975   Curated Info

62

Qin S, De Vries GW (2008) alpha2 But not alpha1 AMP-activated protein kinase mediates oxidative stress-induced inhibition of retinal pigment epithelium cell phagocytosis of photoreceptor outer segments. J Biol Chem 283, 6744-51
18195011   Curated Info

63

Okoshi R, et al. (2008) Activation of AMP-activated protein kinase induces p53-dependent apoptotic cell death in response to energetic stress. J Biol Chem 283, 3979-87
18056705   Curated Info

64

Sanders MJ, et al. (2007) Defining the mechanism of activation of AMP-activated protein kinase by the small molecule A-769662, a member of the thienopyridone family. J Biol Chem 282, 32539-48
17728241   Curated Info

65

Tosca L, Uzbekova S, Chabrolle C, Dupont J (2007) Possible role of 5'AMP-activated protein kinase in the metformin-mediated arrest of bovine oocytes at the germinal vesicle stage during in vitro maturation. Biol Reprod 77, 452-65
17567959   Curated Info

66

Tzatsos A, Tsichlis PN (2007) Energy depletion inhibits phosphatidylinositol 3-kinase/Akt signaling and induces apoptosis via AMP-activated protein kinase-dependent phosphorylation of IRS-1 at Ser-794. J Biol Chem 282, 18069-82
17459875   Curated Info

67

Possemato A (2007) CST Curation Set: 2798; Year: 2007; Biosample/Treatment: cell line, Jurkat/calyculin_A & pervanadate; Disease: T cell leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[ST]Q
Curated Info

68

Roepstorff C, et al. (2006) Higher skeletal muscle alpha2AMPK activation and lower energy charge and fat oxidation in men than in women during submaximal exercise. J Physiol 574, 125-38
16600998   Curated Info

69

McConell GK, et al. (2005) Short-term exercise training in humans reduces AMPK signalling during prolonged exercise independent of muscle glycogen. J Physiol 568, 665-76
16051629   Curated Info

70

Schulz E, Anter E, Zou MH, Keaney JF (2005) Estradiol-mediated endothelial nitric oxide synthase association with heat shock protein 90 requires adenosine monophosphate-dependent protein kinase. Circulation 111, 3473-80
15967841   Curated Info

71

Rafaeloff-Phail R, et al. (2004) Biochemical regulation of mammalian AMP-activated protein kinase activity by NAD and NADH. J Biol Chem 279, 52934-9
15465812   Curated Info

72

Bronner M, Hertz R, Bar-Tana J (2004) Kinase-independent transcriptional co-activation of peroxisome proliferator-activated receptor alpha by AMP-activated protein kinase. Biochem J 384, 295-305
15312046   Curated Info

73

Zang M, et al. (2004) AMP-activated protein kinase is required for the lipid-lowering effect of metformin in insulin-resistant human HepG2 cells. J Biol Chem 279, 47898-905
15371448   Curated Info

74

Nielsen JN, et al. (2003) 5'-AMP-activated protein kinase activity and subunit expression in exercise-trained human skeletal muscle. J Appl Physiol 94, 631-41
12391032   Curated Info

75

Wojtaszewski JF, et al. (2002) Dissociation of AMPK activity and ACCbeta phosphorylation in human muscle during prolonged exercise. Biochem Biophys Res Commun 298, 309-16
12413941   Curated Info