Tyr768
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Home > Phosphorylation Site Page: > Tyr768  -  FLT3 (human)

Site Information
HSEDEIEyENQkRLE   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 459389

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 2 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 , 2 ) , western blotting ( 1 , 2 )
Disease tissue studied:
leukemia ( 1 ) , acute myelogenous leukemia ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Treatments:
FL ( 1 , 2 )

Downstream Regulation
Effects of modification on FLT3:
molecular association, regulation ( 2 )
Effects of modification on biological processes:
cell cycle regulation ( 2 )
Induce interaction with:
GRB2 (human) ( 2 )

References 

1

Razumovskaya E, et al. (2009) Oncogenic Flt3 receptors display different specificity and kinetics of autophosphorylation. Exp Hematol 37, 979-89
19477218   Curated Info

2

Masson K, et al. (2009) A role of Gab2 association in Flt3 ITD mediated Stat5 phosphorylation and cell survival. Br J Haematol 146, 193-202
19438505   Curated Info