Lys840
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Home > Sumoylation Site Page: > Lys840  -  PIK3C3 (mouse)

Site Information
LEPDKTVkKVQDKFR   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 31077507

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , western blotting ( 1 )
Disease tissue studied:
PAH ( 1 )
Relevant cell line - cell type - tissue:
'muscle, smooth'-pulmonary artery ( 1 ) , MOVAS-1 (VSMC) ( 1 )

Upstream Regulation
Regulatory protein:
SUMO1 (mouse) ( 1 )
Treatments:
hypoxia ( 1 )

Downstream Regulation
Effects of modification on PIK3C3:
molecular association, regulation ( 1 )
Effects of modification on biological processes:
autophagy, induced ( 1 ) , cell differentiation, altered ( 1 )

Disease / Diagnostics Relevance
Relevant diseases:
PAH ( 1 )

References 

1

Yao Y, et al. (2019) SUMOylation of Vps34 by SUMO1 promotes phenotypic switching of vascular smooth muscle cells by activating autophagy in pulmonary arterial hypertension. Pulm Pharmacol Ther 55, 38-49
30703554   Curated Info

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