Lys6
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Home > Sumoylation Site Page: > Lys6  -  PIN1 (human)

Site Information
__MADEEkLPPGWEk   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 31094510

In vivo Characterization
Methods used to characterize site in vivo:
electrophoretic mobility shift ( 2 ) , immunoprecipitation ( 2 ) , mass spectrometry ( 1 , 2 ) , modification-specific antibody ( 2 ) , mutation of modification site ( 2 ) , western blotting ( 2 )
Disease tissue studied:
breast cancer ( 2 ) , breast adenocarcinoma ( 2 ) , breast cancer, triple negative ( 2 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Regulatory protein:
SENP2 (human) ( 2 ) , SENP3 (human) ( 2 )
Treatments:
H2O2 ( 2 ) , siRNA ( 2 )

Downstream Regulation
Effects of modification on PIN1:
enzymatic activity, inhibited ( 2 ) , molecular association, regulation ( 2 ) , protein degradation ( 2 )
Effects of modification on biological processes:
carcinogenesis, inhibited ( 2 ) , cell growth, inhibited ( 2 ) , transcription, inhibited ( 2 )
Inhibit interaction with:
FOXM1 (mouse) ( 2 )

References 

1

Tammsalu T, et al. (2014) Proteome-wide identification of SUMO2 modification sites. Sci Signal 7, rs2
24782567   Curated Info

2

Chen CH, et al. (2013) SENP1 deSUMOylates and Regulates Pin1 Protein Activity and Cellular Function. Cancer Res 73, 3951-62
23633483   Curated Info