Thr265
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Home > Phosphorylation Site Page: > Thr265  -  Ets-1 (human)

Site Information
yDsCDRLtQsWssQs   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 31087093

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 2 ) , mass spectrometry (in vitro) ( 1 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
ovarian cancer ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
GSK3B (human) ( 1 )
Treatments:
LY2090314 ( 1 ) , siRNA ( 1 )

Downstream Regulation
Effects of modification on Ets-1:
activity, induced ( 1 ) , molecular association, regulation ( 1 ) , protein stabilization ( 1 )
Effects of modification on biological processes:
carcinogenesis, induced ( 1 ) , cell motility, induced ( 1 ) , signaling pathway regulation ( 1 ) , transcription, induced ( 1 )
Induce interaction with:
DNA ( 1 ) , p300 (human) ( 1 )

Disease / Diagnostics Relevance
Relevant diseases:
ovarian cancer ( 1 )

References 

1

Tsai CL, et al. (2021) Glycogen synthase kinase-3 beta (GSK3β)-mediated phosphorylation of ETS1 promotes progression of ovarian carcinoma. Aging (Albany NY) 13
34023818   Curated Info

2

Zhou H, et al. (2013) Toward a comprehensive characterization of a human cancer cell phosphoproteome. J Proteome Res 12, 260-71
23186163   Curated Info