Ser6
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Home > Phosphorylation Site Page: > Ser6  -  RBM21 (human)

Site Information
__MAAVDsDVEsLPr   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 31080908

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 , 2 ) , mass spectrometry ( 2 , 3 , 4 , 5 , 7 ) , mutation of modification site ( 1 , 2 ) , phospho-antibody ( 2 ) , western blotting ( 2 )
Disease tissue studied:
breast cancer ( 1 ) , melanoma skin cancer ( 3 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
CK1A (human) ( 2 )
Kinases, in vitro:
CK1A (human) ( 2 )

Downstream Regulation
Effects of modification on RBM21:
molecular association, regulation ( 1 , 2 )
Effects of modification on biological processes:
transcription, induced ( 2 ) , translation, induced ( 1 )
Induce interaction with:
RBM21 (human) ( 2 ) , RNA ( 2 )

References 

1

Sudheesh AP, Laishram RS (2017) Nuclear phosphatidyl-inositol-phosphate type I kinase ╬▒ coupled Star-PAP polyadenylation regulates cell invasion. Mol Cell Biol
29203642   Curated Info

2

Mohan N, et al. (2015) Phosphorylation regulates the Star-PAP-PIPKI╬▒ interaction and directs specificity toward mRNA targets. Nucleic Acids Res 43, 7005-20
26138484   Curated Info

3

Stuart SA, et al. (2015) A Phosphoproteomic Comparison of B-RAFV600E and MKK1/2 Inhibitors in Melanoma Cells. Mol Cell Proteomics 14, 1599-615
25850435   Curated Info

4

Mertins P, et al. (2013) Integrated proteomic analysis of post-translational modifications by serial enrichment. Nat Methods 10, 634-7
23749302   Curated Info

5

Zhou H, et al. (2013) Toward a comprehensive characterization of a human cancer cell phosphoproteome. J Proteome Res 12, 260-71
23186163   Curated Info

6

Beli P, et al. (2012) Proteomic Investigations Reveal a Role for RNA Processing Factor THRAP3 in the DNA Damage Response. Mol Cell 46, 212-25
22424773   Curated Info

7

Pan C, Olsen JV, Daub H, Mann M (2009) Global effects of kinase inhibitors on signaling networks revealed by quantitative phosphoproteomics. Mol Cell Proteomics 8, 2796-808
19651622   Curated Info