Ser308
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Home > Phosphorylation Site Page: > Ser308  -  SREBP-1 iso1 (rat)

Site Information
IEKRYRSsINDKIVE   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 458357

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 , 2 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 1 ) , COS (fibroblast) ( 2 ) , hepatocyte ( 2 )

Upstream Regulation
Kinases, in vitro:
PKACA (human) ( 2 )

Downstream Regulation
Effects of modification on SREBP-1 iso1:
protein degradation ( 2 ) , sumoylation ( 2 ) , ubiquitination ( 2 )
Effects of modification on biological processes:
transcription, inhibited ( 1 , 2 )

References 

1

Dong Q, et al. (2014) Phosphorylation of sterol regulatory element binding protein-1a by protein kinase A (PKA) regulates transcriptional activity. Biochem Biophys Res Commun 449, 449-54
24853806   Curated Info

2

Lee GY, et al. (2014) PIASy-Mediated Sumoylation of SREBP1c Regulates Hepatic Lipid Metabolism upon Fasting Signaling. Mol Cell Biol 34, 926-38
24379443   Curated Info

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