Thr112
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Home > Phosphorylation Site Page: > Thr112  -  CTNNB1 (human)

Site Information
EGMQIPStQFdAAHP   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 3075001

In vivo Characterization
Methods used to characterize site in vivo:
electrophoretic mobility shift ( 1 ) , mutation of modification site ( 1 , 2 ) , phospho-antibody ( 2 ) , western blotting ( 1 , 2 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
PRKD1 (human) ( 1 )
Kinases, in vitro:
CK2A2 (human) ( 2 ) , PRKD1 (human) ( 1 )

Downstream Regulation
Effects of modification on CTNNB1:
intracellular localization ( 1 ) , protein degradation ( 2 )
Effects of modification on biological processes:
cell growth, inhibited ( 1 ) , cell motility, altered ( 2 ) , cell motility, inhibited ( 1 ) , transcription, induced ( 1 )
Induce interaction with:
CTNNA1 (human) ( 2 )

References 

1

Du C, Jaggi M, Zhang C, Balaji KC (2009) Protein kinase D1-mediated phosphorylation and subcellular localization of beta-catenin. Cancer Res 69, 1117-24
19141652   Curated Info

2

Bek S, Kemler R (2002) Protein kinase CKII regulates the interaction of beta-catenin with alpha-catenin and its protein stability. J Cell Sci 115, 4743-53
12432063   Curated Info